Not Yet RecruitingNot Applicable

The Effect of Motivational Interviewing on Treatment Adherence and Self-Efficacy Among Omani Adults With Thalassemia

45 participantsStarted 2026-11-01

Plain-language summary

Beta-thalassemia major is a chronic hereditary blood disorder that requires lifelong treatment, including regular blood transfusions and iron chelation therapy. Poor adherence to treatment remains a significant challenge and may lead to iron overload and related complications. Self-efficacy is an important factor influencing patients' ability to adhere to treatment recommendations. This study aims to evaluate the effect of nurse-delivered Motivational Interviewing (MI) on treatment adherence and self-efficacy among Omani adults with beta-thalassemia major. A pre-experimental one-group repeated-measures design will be used. Approximately 45 participants will be recruited from the Oman National Center for Hematology and Bone Marrow Transplantation and Royal Hospital in Muscat, Oman. Participants will receive three individualized MI sessions over a period of six to eight weeks. Treatment adherence and self-efficacy will be assessed at baseline, immediately after completion of the intervention, and at three-month follow-up. Secondary outcomes include serum ferritin level and frequency of thalassemia-related hospital admissions. The findings will provide evidence regarding the usefulness of motivational interviewing in improving adherence-related outcomes among adults with beta-thalassemia major.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 years and older. * Diagnosed with transfusion-dependent beta-thalassemia major. * Receiving iron chelation therapy for at least 6 months. * Receiving regular follow-up at the participating study sites. * Able to communicate in Arabic or English. * Willing and able to provide informed consent. * Able to attend the motivational interviewing sessions and complete study questionnaires. Exclusion Criteria: * Current hospitalization for an acute medical condition at the time of recruitment. * Severe cognitive impairment or psychiatric illness that may affect participation. * Participation in another structured psychosocial or behavioral intervention program. * Unable or unwilling to provide informed consent.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Treatment Adherence

Timeframe: Baseline, post-intervention (after completion of the third motivational interviewing session), and 3-month follow-up

Self-Efficacy

Timeframe: Baseline, post-intervention (after completion of the third motivational interviewing session), and 3-month follow-up

Trial details

NCT IDNCT07660224

SponsorOman Ministry of Health

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2027-08-10

Contact for this trial

Mizna Said Al-sinani, RN, BSN

968-99851427 s100722@student.squ.edu.om

View on ClinicalTrials.gov More Beta-Thalassemia Major trials