CompletedNot Applicable

Research on the Possible Relationship Between Sarcopenia and Oral Muscle Function

Taiwan251 participantsStarted 2025-11-14

Plain-language summary

This study will focus on community-dwelling elderly individuals and will follow the community screening process recommended by AWGS. It is expected to recruit 100 individuals who may have sarcopenia and 300 healthy or sub-healthy elderly individuals who are not likely to have sarcopenia, totaling 400 participants.Basic data such as age and body composition will be collected, as well as dietary records (three days), nutritional status assessments (Mini Nutritional Assessment, MNA), and oral health status records (including records of missing teeth, the number of opposing teeth, and whether participants wear fixed or removable dentures). Chewing and swallowing abilities will be recorded using the Eating Assessment Tool (EAT-10). In a non-invasive manner, saliva samples will be collected for genomic DNA (gDNA) extraction, followed by quantitative gDNA typing analysis of seven gene loci (shown in Table 3). Genotype data will be statistically analyzed along with participants' basic information, relevant sarcopenia screening data, and parameters related to oral health and swallowing function. This study adopts a case-control experimental design with the following objectives: 1. to explore the incidence of possible sarcopenia in community-dwelling elderly. 2. to investigate the relationship between oral function and possible sarcopenia in community-dwelling elderly using tongue pressure measurements. 3. to understand the correlation between sarcopenia risk in community-dwelling elderly and seven specific genes. 4. to examine the relationship between oral function and seven specific genes in community-dwelling elderly. 5. to investigate the relationship between tongue pressure measurements and the values measured using edible chewing gum. 6. to establish a standard test for evaluating oral chewing function using edible chewing gum. By examining the possible mechanisms of the different genes involved in the causes of sarcopenia, we aim to find prevention strategies that are suitable for participants with different gene types.

Who can participate

Age range

60 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Case group - Inclusion Criteria: * aged 60 years (inclusive) or older * general public or residing in an institution for 3 months (inclusive) or more * willing to participate in the experimental design and sign the consent form * able to eat independently by mouth * identified by researchers as possibly having sarcopenia Control group-Inclusion Criteria: * aged 60 years (inclusive) or older * general public or residing in an institution for 3 months (inclusive) or more ●willing to participate in the experimental design and sign the consent form * able to eat independently by mouth * identified by researchers as not possibly having sarcopenia Case group 、Control group- Exclusion Criteria: * having comorbidities, critical illnesses, undergoing major surgeries, cancer, renal failure, liver failure, kidney diseases, liver diseases, having malignant tumors in the past five years, inflammation symptoms (C-reactive protein \>10mg/dl) * severely malnourished individuals (GNRI \< 82) * long-term tube-fed individuals.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Based on the results of empirical research on sarcopenia in Asian countries, a diagnostic consensus was established.

Timeframe: baseline

Trial details

NCT IDNCT07658612

SponsorChang Gung University of Science and Technology

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-06-04

View on ClinicalTrials.gov More Non-sarcopenic Subjects trials