AI Multimodal Model for Liver Cancer Diagnosis and Prognosis (NCT07658586) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
AI Multimodal Model for Liver Cancer Diagnosis and Prognosis
China600 participantsStarted 2025-12-01
Plain-language summary
This study aims to develop a comprehensive artificial intelligence model system integrating preoperative multimodal data (CT/MRI imaging, clinical laboratory data, and radiology report text) to achieve two core objectives. First, to develop a multimodal fusion diagnostic model for non-invasive and accurate preoperative differentiation of liver cancer subtypes, including distinguishing benign from malignant lesions and differentiating hepatocellular carcinoma from intrahepatic cholangiocarcinoma. Second, to develop a prognostic prediction model for patients with confirmed liver cancer undergoing radical surgery to assess postoperative progression-free survival and overall survival. This is a multicenter retrospective cohort study with an anticipated sample size of ≥600 patients. Model performance will be evaluated using AUC, accuracy, sensitivity, specificity, C-index, and calibration curves. Subgroup analysis will be conducted based on whether patients received neoadjuvant therapy.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
Diagnostic Model Cohort: (1) Age ≥18 years; (2) Underwent preoperative contrast-enhanced CT or MRI for clinically suspected liver space-occupying lesion; (3) Have complete preoperative clinical laboratory data; (4) Have complete original CT/MRI imaging data and radiology reports; (5) Have definite pathological diagnosis from surgery or biopsy as gold standard. Prognostic Prediction Model Cohort (selected from diagnostic cohort): (1) Meet all diagnostic cohort inclusion criteria and have pathologically confirmed liver cancer; (2) Underwent radical hepatectomy; (3) Have complete preoperative multimodal data (CT/MRI imaging, clinical laboratory data, radiology reports); (4) Have complete postoperative follow-up data to determine progression-free survival and overall survival endpoints and time (minimum follow-up of 24 months).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Diagnostic Accuracy of the Multimodal AI Model for Liver Lesion Classification
Timeframe: At the time of initial diagnosis
2
Prognostic Performance of the Multimodal AI Model for Postoperative Survival Prediction