Combined SPSP and TTP Blocks for Postoperative Analgesia Post-CABG (NCT07658521) | Clinical Trial Compass
By InvitationNot Applicable
Combined SPSP and TTP Blocks for Postoperative Analgesia Post-CABG
Egypt88 participantsStarted 2026-07-01
Plain-language summary
The goal of this clinical trial is to learn if combining two ultrasound-guided nerve blocks - one for the front of the chest and one for the side of the chest - works better than standard pain medications alone to treat pain after coronary artery bypass grafting (CABG) surgery. It will also learn about the safety of these nerve blocks. The main questions it aims to answer are:
Does the combined nerve block approach lower the amount of opioid pain medication needed in the first 24 hours after surgery? Does the combined nerve block approach lower pain scores at rest and with movement compared to standard care? What medical problems do participants have when receiving the nerve blocks (such as bleeding, infection, or effects from the local anesthetic)? Researchers will compare the combined nerve block group to a standard care group (no nerve blocks) to see if the blocks improve pain control and recovery after heart surgery.
Participants will:
Be randomly assigned to one of two groups: (1) combined nerve blocks plus standard pain medications, or (2) standard pain medications alone Receive the nerve blocks during surgery while under general anesthesia (if assigned to the block group) Have their pain levels checked regularly using a 0-10 scale for the first 48 hours after surgery Have their breathing, walking time, and opioid medication use monitored during their hospital stay Complete a satisfaction survey about their pain management before leaving the hospital Stay in the hospital for their routine recovery period (typically 5-7 days) with no extra visits required
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18-65 years.
* Scheduled for elective, isolated CABG via median sternotomy.
* American Society of Anesthesiologists (ASA) physical status II-III.
* Ability to understand the study procedures, provide written informed consent, and reliably report pain scores using the NRS.
Exclusion Criteria:
* Emergency surgery or pre-operative hemodynamics instability.
* Known allergies or hypersensitivity to local anesthetics, paracetamol, morphine, or any study medication.
* Coagulopathy, uncontrolled bleeding risk, or therapeutic anticoagulation that cannot be safely withheld per institutional guidelines (INR \> 1.5; platelets \< 100 × 10⁹/L at time of block).
* Local infection or cellulitis at any planned injection site on the anterior or lateral chest wall.
* Pre-existing chronic pain syndrome requiring daily opioid analgesia or known opioid dependence.
* Significant cognitive impairment, severe psychiatric disorder, or inability to reliably use pain scales.
* History of prior thoracic surgery or major chest wall deformity distorting anatomy or limiting the ultrasound window.
* Pregnancy or breastfeeding.
* Any other condition judged by the investigator to represent unacceptable risk or preclude study participation.
* Patient refusal or withdrawal of consent.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Accumulated from time of tracheal extubation through 48 hours post-extubation
Timeframe: rom time of tracheal extubation until administration of first rescue IV morphine dose for NRS ≥ 4, assessed up to 48 hours post-extubation