Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia (NCT07658508) | Clinical Trial Compass
Active — Not RecruitingPhase 2/3
Topical Calcipotriol Versus Photodynamic Therapy in the Treatment of Oral Leukoplakia
Egypt30 participantsStarted 2025-07-16
Plain-language summary
The goal of this clinical trial is to learn if calcipotriol and photodynamic therapy are equally effective in treatment of leukoplakia or not. The main questions it aims to answer are:
do lesions decrease or disappear when treated by calcipotriol or PDT? does the drug affect the salivary biomarkers
Participants will:
Take calcipotriol daily for 4 weeks or perform 4 PDT sessions over 4 weeks measure changes in salivary biomarkers be followed up for 3 months
Who can participate
Age range
25 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients, both males and females, 25 to 55years old will be included in this clinical trial.
* Patients with oral leukoplakia with histologically confirmed mild and moderate epithelial dysplasia.
* Patients willing and able to return for multiple follow up visits
Exclusion Criteria:
* Presence of any visible oral lesions other than leukoplakia.
* Periodontitis patients: since chronic periodontitis may affect salivary TNF-alpha and MMP-9 level.
* Contraindications for the use of calcipotriol or amino levulonic acid as allergy.
* History of topical and/or systemic therapy for 2 months before the start of study.
* Patients with conditions that could affect saliva collection as xerostomia.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.