Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease (NCT07657624) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease
China2,352 participantsStarted 2026-06-30
Plain-language summary
This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic parameters and multimodal imaging features. A total of 2,352 participants will be enrolled from Beijing Anzhen Hospital, Capital Medical University, China. Eligible participants are adults (≥18 years) with confirmed CHD who undergo systematic neuropsychological assessment during hospitalization. Comprehensive assessments include cognitive function tests (MMSE, MoCA, BCAT, AD8), metabolic evaluations (fasting glucose, insulin, HbA1c, ceramides), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), sleep respiratory monitoring, and frailty and psychological assessments.The primary outcome is cognitive impairment. The study will identify potential risk factors and provide insights into early identification and personalized intervention strategies for cognitive decline in CHD patients.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥ 18 years
. Diagnosis of coronary heart disease (meeting at least one of the following):
. Completion of standardized neuropsychological assessment during hospitalization
. Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments
. Provision of signed written informed consent
Exclusion criteria
. Previously diagnosed dementia.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is focused on modifiable risk factors — things that can potentially be changed — that link coronary heart disease to mild cognitive impairment. Can you help me understand which of my current risk factors, like blood pressure, cholesterol, or lifestyle habits, might already be putting my cognition at risk and whether addressing them now could help?
2The trial hasn't started recruiting yet — what does that mean for my timeline if I'm interested, and is there any standard care or existing program that addresses the overlap between heart disease and cognitive health that I could pursue in the meantime?
3Since this study is listed as 'Phase NA,' it sounds like it may be an observational or registry-type study rather than one testing a new treatment — can you clarify what participation would actually involve for me, and whether I'd be receiving any active intervention or just being monitored?
4The study is specifically measuring cognitive impairment as the primary outcome — would I need to undergo cognitive testing as part of this trial, and how might the results of that testing be shared with me and used in my ongoing care?
5Given that I have coronary heart disease, are there already evidence-based steps my care team recommends to protect my cognitive health, and how does joining a study like this compare to simply focusing on those established strategies?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.