Daily Versus Alternate-Day Oral Iron Therapy for Anemia in Second-Trimester Pregnancy (NCT07657455) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Daily Versus Alternate-Day Oral Iron Therapy for Anemia in Second-Trimester Pregnancy
Pakistan184 participantsStarted 2026-09
Plain-language summary
This randomized controlled trial compares daily versus alternate-day oral iron supplementation in pregnant women with iron deficiency anemia during the second trimester. The study evaluates changes in hemoglobin and serum ferritin, treatment adherence, and gastrointestinal side effects to inform more patient-centered, physiologically aligned dosing strategies.
Who can participate
Age range
18 Years – 40 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Aged 18 to 40 years
* Pregnant women in the second trimester (13 to 27 weeks gestation)
* Hemoglobin below 11 g/dL with serum ferritin below 30 ng/mL
* Singleton pregnancy
Exclusion Criteria:
* Known congenital or acquired hemoglobin disorders (e.g., thalassemia, hemoglobinopathies)
* Chronic diseases affecting hemoglobin levels (e.g., chronic kidney disease, inflammatory disorders)
* Bleeding disorders or a history of frequent blood loss
* Gastrointestinal conditions impairing nutrient absorption (e.g., celiac disease or other malabsorption syndromes)
* Currently receiving parenteral iron
* Requiring blood transfusion
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in hemoglobin from baseline to Week 4
Timeframe: Baseline and Week 4
Trial details
NCT IDNCT07657455
SponsorPakistan Air Force (PAF) Hospital Islamabad