Taurine and Nitrate Supplementation on Thermoregulatory in T2DM (NCT07656051) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Taurine and Nitrate Supplementation on Thermoregulatory in T2DM
18 participantsStarted 2026-06-01
Plain-language summary
Anthropogenic warming is increasing the frequency and intensity of extreme heat events. Elevated temperatures raise the risk of mortality and hospital admissions, particularly among people with chronic illnesses such as type 2 diabetes mellitus (T2DM). Globally, around 530 million people live with T2DM , and in the United Kingdom nearly six million are affected, creating a substantial population vulnerable to heat related illness.
People with T2DM are at heightened risk of cardiovascular disease, which can impair cardiac output, a key component of thermoregulation, as it supports increased skin blood flow for heat dissipation. T2DM also attenuates eccrine sweat gland function, peripheral vasodilation, reducing evaporative cooling capacity. These physiological constraints highlight the need for effective strategies to improve heat tolerance in this group.
Recent evidence shows that exogenous taurine supplementation can enhance sweating in healthy individuals, potentially improving heat loss. This study will examine whether acute taurine supplementation, alone or combined with beetroot, can limit rises in core temperature in people with T2DM during an acute extreme heat exposure.
Who can participate
Age range
35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male or female (post-menopausal) aged 35 years or above.
* Diagnosed with T2DM as defined by the WHO (HbA1c ≥48 mmol/mol).
* Willing and able to give informed consent for participation in the study.
* Able to understand and fully cooperate with the study protocol.
Exclusion Criteria:
* Severe peripheral neuropathy (to the point to which they cannot sense temperature)
* Uncontrolled hypertension (≥180 systolic / 100 diastolic)
* Significant renal impairment (eGFR \< 30)
* Diagnosed anhidrosis
* Taking any medication which may interfere with data interpretation or safety
* Who have had a myocardial infarction or cerebrovascular event
* Any cardiac abnormalities which restrict hard exercise
* Any allergies to the ingredients used in the supplements
* BMI \>40
* Current smokers or who have stopped within 3 months
* Unable to understand and/or fully cooperate with the study protocol
* Any serious medical condition which would interfere with data interpretation or safety will be excluded from participation.
* Open wounds
* Skin ulcerations (that would interfere with data collection and interpretation or safety)
* Eczema (that would interfere with data collection and interpretation or safety)
* Pre-existing postural hypertension
* Existing cardiac diseases (identified during screening)
* Currently heat acclimated (repeated exposure to hot environments ≥3 sessions in the last 14-21 days)
* Prior heat related illness
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying how taurine and nitrate supplements affect sweating in people with Type 2 Diabetes — could you help me understand why impaired sweating matters for my diabetes management and whether this is something I personally struggle with?
2Since this trial hasn't started recruiting yet, is it worth waiting to see if I might be eligible once it opens, or would starting standard diabetes treatment now make more sense for where I am in my diagnosis?
3The study involves taking taurine and nitrate as supplements — are either of these known to interact with any diabetes medications I'm already taking or might be prescribed?
4This trial is listed as Phase NA, which often applies to studies focused on understanding body processes rather than testing a treatment — can you explain what that means for what I'd actually gain from participating, since it may not directly change my care?
5If improving how my body regulates heat and sweating is a real concern for me as someone with Type 2 Diabetes, are there other approaches or existing treatments my care team would recommend I look into while this trial is still in its pre-recruitment phase?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Whole body sweat rate
Timeframe: Baseline and immediately post heating (3 hour post-baseline)