Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major … (NCT07655687) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Targeted Temperature Management on Delayed Neurocognitive Recovery in Older Patients After Major Cancer Surgery
China1,512 participantsStarted 2026-06
Plain-language summary
With aging population, more older patients will receive major surgery for cancer. Older patients are at increased risk of postoperative neurocognitive complications including delayed neurocognitive recovery (dNCR), which is associated with prolonged hospital stay, raised complications, and impaired quality of life. Intraoperative hypothermia occurs in 57.1%-78.6% of patients undergoing major cancer surgery, especially in the elderly. Studies show that intraoperative hypothermia suppresses immune function, interferes with anesthetic metabolism, and delays anesthesia emergence. All these may be correlated with the occurrence of early postoperative dNCR. This study aims to verify whether intraoperative targeted temperature management (target core temperature: 36.8°C) compared with conventional temperature management (core temperature: 35.5°C) can reduce the incidence of dNCR in older patients undergoing major cancer surgery.
Who can participate
Age range
65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age ≥ 65 years.
. Planned potentially curative initial cancer surgery with an expected duration of 2 hours or longer under general anesthesia.
Exclusion criteria
. Preoperative fever (tympanic temperature ≥ 38℃).
. Inability to communicate due to coma, severe dementia, or hearing or speech impairment.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is specifically studying delayed neurocognitive recovery in older patients after major cancer surgery — can you explain what delayed neurocognitive recovery actually is, and whether my age and planned surgery put me at higher risk for it?
2The trial uses targeted temperature management, which involves deliberately controlling a patient's body temperature — can you walk me through what that process would actually look like during and after my surgery, and what discomforts or risks it might add?
3Since this trial is listed as 'not yet recruiting,' what is your best estimate of when it might open, and is waiting for it a realistic option given the timeline of my cancer treatment?
4The trial is listed as Phase NA, which suggests it may be exploring whether this approach even works rather than confirming proven benefit — given that uncertainty, how does participating compare to just having my surgery done the standard way at a center that already has experience with cognitive outcomes in older patients?
5Are there any other steps already available — like established care protocols for preventing cognitive decline after surgery — that my care team would use regardless of whether I joined this trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of delayed neurocognitive recovery (dNCR)
Timeframe: At 5 days after surgery or before hospital discharge, whichever came first
. Critically ill patients, defined as NYHA functional class \> III or LVEF \< 30%, Child-Pugh class C, preoperative dialysis dependence, ASA physical status \> IV, or expected survival \< 24 hours.
. Surgery for breast cancer, intracranial tumors, or rare cancers.
. Planned to undergo therapeutic hypothermia.
. Body mass index \> 30 kg/m² (to facilitate temperature management).