Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infect… (NCT07655596) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients.
100 participantsStarted 2026-07-01
Plain-language summary
A randomized controlled trial on adults who underwent orthopedic surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing SSIs in the orthopedic surgical population.
Eligible patients will be randomized in a block design into 2 groups: intervention and control. The intervention group will use continuous infusion of cefazolin (CI), while the control group will follow the traditional presurgical prophylaxis protocol of intermittent cefazolin doses (INT).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Orthopaedic surgical ward patients who underwent major surgery.
Exclusion Criteria:
* Patients who require reoperation within 30 days.
* Immunosuppressant patients.
* Patients who are not adherent to the protocol time or dosing, either preoperatively, during, or postoperatively.
* Pregnancy or breastfeeding.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is comparing two different ways of giving cefazolin — a continuous drip versus periodic bolus injections — during orthopedic surgery; which method does my current surgical team already use, and how might participating in this trial change my standard antibiotic care?
2Since this is a Phase 4 trial, cefazolin itself is already an approved and established antibiotic, but the delivery method is still being studied — does that mean the safety profile is well understood, and what, if anything, is still uncertain about one method versus the other?
3The trial is not yet recruiting and is being conducted in Egyptian patients specifically — do you know when it might open, whether I would even be eligible to participate, and if there are geographic or logistical factors that could affect my ability to join?
4The main thing being measured is whether surgical site infection rates differ between the two antibiotic delivery methods — based on what's already known, does my doctor have a preference for one approach for my specific type of orthopedic surgery?
5If I don't participate in this trial, what antibiotic prevention approach would I receive as standard care, and is there any reason to think waiting for this trial's results might influence decisions about my surgery timing?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.