CompletedNot Applicable

Electromyographic Response to Blood Flow Restriction Exercise in Healthy Adults

Spain24 participantsStarted 2026-02-01

Plain-language summary

This study evaluated the immediate neuromuscular response to low-load knee extension exercise performed with and without blood flow restriction in healthy young adults. Blood flow restriction is a training method in which a pressure cuff is applied to the upper part of a limb to partially reduce blood flow during exercise. In this study, each participant completed the same knee extension exercise protocol under two conditions: with blood flow restriction and without blood flow restriction. The blood flow restriction pressure was individualized according to each participant's arterial occlusion pressure. Surface electromyography was used to record the activity of the vastus lateralis muscle during the exercise protocol. Muscle activation was mainly assessed using the root mean square amplitude normalized to a maximal voluntary isometric contraction measured before exercise. Maximal voluntary isometric contraction was also recorded before and after the protocol to explore immediate changes in maximal muscle activation. The study was conducted in healthy adults and aimed to compare the electromyographic response between the blood flow restriction and non-restriction conditions during a standardized low-load exercise task.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 18 and 65 years. * Healthy adults. * Absence of active pain or musculoskeletal injury in the lower limbs at the time of assessment. * Ability to understand the study procedures. * Voluntary agreement to participate and provision of written informed consent. Exclusion Criteria: * History of neuromuscular disease. * History of cardiovascular disease. * History of peripheral vascular disease. * History of thromboembolic events. * Uncontrolled hypertension. * Skin lesions or skin conditions preventing placement of the blood flow restriction cuff or surface electromyography electrodes. * Recent lower limb surgery. * Pregnancy. * Any other contraindication to blood flow restriction exercise.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Vastus Lateralis Electromyographic Amplitude Normalized to Maximal Voluntary Isometric Contraction

Timeframe: During the exercise protocol, within a single experimental session.

Trial details

NCT IDNCT07654608

SponsorUniversidad de Extremadura

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-15

View on ClinicalTrials.gov More Electromyographic Response to Blood Flow Restriction Exercise in Healthy Adults trials