Guided Bone Regeneration Combined With PRGF for Atrophic Edentulous Maxilla

Inclusion Criteria: Age 18 years or older. Fully edentulous maxilla requiring implant-supported fixed oral rehabilitation. Atrophic maxillary alveolar ridge requiring vertical and/or horizontal bone augmentation before implant placement. Residual alveolar ridge width below 6 mm and/or residual bone height below 10 mm, as assessed by cone-beam computed tomography. ASA physical status I or II. Clinical indication for guided bone regeneration, with or without simultaneous maxillary sinus floor elevation. Adequate oral hygiene and willingness to comply with postoperative instructions and follow-up visits. Written informed consent provided. Exclusion Criteria: ASA physical status III or higher. Uncontrolled systemic disease contraindicating oral surgery or bone regenerative procedures. Uncontrolled diabetes mellitus or other systemic condition expected to impair wound healing or bone regeneration. History of radiotherapy to the head and neck region. Current or previous intravenous antiresorptive or antiangiogenic therapy associated with risk of medication-related osteonecrosis of the jaw. Active oral infection at the surgical site. Untreated periodontal disease or poor oral hygiene incompatible with regenerative surgery. Heavy smoking or unwillingness to comply with perioperative smoking restrictions. Pregnancy or breastfeeding. Inability to understand the study procedures or provide informed consent. Inability or unwillingness to attend scheduled follow-up visits. Any…