Stopped: We were able to test our hypothesis using the current data
Mucosal healing is recognized hitherto as the best therapeutic endpoint in patients with Ulcerative Colitis (UC) but its use in daily practice is limited by the low acceptability of repeated colonoscopies. In this context, fecal biomarkers are attractive alternatives. Fecal calprotectin showed very good negative predictive value to eliminate IBD diagnosis, good correlation to endoscopic activity and good ability to predict relapse. Recently, several teams including ours, showed that fecal biomarkers such as Chitinase 3-Like 1 (CHI3L1), matrix metalloprotease type 9 (MMP-9) and serum biomarkers neutrophil gelatinase B- complex associated lipocalin (NGAL)-MMP9 and serum CHI3L1 could be better biomarkers than fecal calprotectin to assess endoscopic activity in patients with UC.
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Serum measurements: CHI3L1 and NGAL-MMP9
Timeframe: Serum change from baseline to month 3
Serum measurements: CHI3L1 and NGAL-MMP9
Timeframe: Serum change from baseline to month 6
Serum measurements: CHI3L1 and NGAL-MMP9
Timeframe: Serum change from baseline to month 9
Serum measurements: CHI3L1 and NGAL-MMP9
Timeframe: Serum change from baseline to month 12
Fecal measurements: CHI3L1, MMP9
Timeframe: Comparison between baseline and month 3
Fecal measurements: CHI3L1, MMP9
Timeframe: Comparison between baseline and month 6
Fecal measurements: CHI3L1, MMP9
Timeframe: Comparison between baseline and month 9
Fecal measurements: CHI3L1, MMP9
Timeframe: Comparison between baseline and month 12