TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) (NCT07653594) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE)
United States20 participantsStarted 2027-01
Plain-language summary
Participants may take part in this study if they are scheduled to undergo a surgery that meets the following: (1) traditional open surgery via laparotomy, (2) length of surgery \>3 hours, and (3) curative-intent surgical resection of a cancer in the stomach, pancreas, bile ducts, liver, or peritoneal surfaces. The purpose of this study is (1) to evaluate the feasibility of collecting blood samples prior to surgery, post-surgery and pre- music-assisted relaxation and imagery (MARI) intervention, and immediately post-MARI intervention and (2) to identify gene expression changes associated with MARI and explore their relationship with immediate changes in pain intensity. Participants will be in this study for the duration of their hospital admission for surgery.
Who can participate
Age range
50 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 50 to 80
* Able to speak and understand English
* Scheduled to undergo a surgery meeting the following criteria: (1) traditional open surgery (not laparoscopic or robotic) via laparotomy (midline or subcostal incisions), (2) length of surgery \>3 hours, and (3) curative-intent surgical resection of a cancer in the stomach, pancreas, bile ducts, liver, or peritoneal surfaces
* Participant reports pain intensity of 4/10 or above to study staff on day 1 post-surgery or any other day post-surgery through discharge
Exclusion Criteria:
* Significant visual impairment that has not been corrected
* Significant hearing impairment that has not been corrected
* Significant cognitive impairment that would prevent participant from participating in the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial seems to be studying how music therapy affects pain pathways in people having surgery for cancers like stomach, pancreatic, bile duct, liver, or peritoneal cancer — is my specific cancer type and planned surgery the kind this study is designed for?
2The trial is measuring whether blood samples can be successfully collected at three specific time points around surgery and a procedure called MARI — can you explain what MARI is, what the blood draws involve, and how realistic it is to fit all of that around my surgical recovery?
3Since this trial isn't recruiting yet, how might the timing of when it opens affect my treatment planning, and should I be considering standard-of-care options now rather than waiting to see if I might be eligible?
4The study phase is listed as 'NA,' which suggests this may be focused more on feasibility and data collection than on testing a treatment — does that mean there's no direct therapeutic benefit being tested for me, and what would my participation actually involve beyond standard surgical care?
5If I were to discuss this trial with your team, what would disqualify me from being considered, and are there other music therapy or integrative medicine approaches already available to me outside of a clinical trial setting?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of participants whose phlebotomy was collected prior to surgery
Timeframe: Within 2 weeks prior to surgery
2
Proportion of participants whose phlebotomy was collected post-surgery (pre-MARI)
Timeframe: Post-surgery and prior to MARI intervention (up to 30 days)
3
Proportion of participants whose phlebotomy was collected post-MARI