The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication

Inclusion Criteria: * Initiating GLP-1 RAs prescribed by physician or advanced practice practitioner and willing to withhold the start of the drug until baseline assessment completed * Non-Smoker * ≥18 years old * Obese: Body Mass Index 30-45 kg/m² or BMI ≥27 + ≥1 weight related comorbidity; either hypertension or sleep apnea confirmed by participant self-report * Inactive: not meeting the current US exercise guidelines over the past 6 months * Capable of performing the required exercise training Exclusion Criteria: * A serious heart condition, such as unstable heart disease or heart failure, irregular heartbeats that are not well controlled, severe narrowing of the heart valves, or any recent inflammation of the heart or its lining * Cancer requiring treatment in the past 5 years * Hypothyroidism/hyperthyroidism * Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome type 2 (MEN2) * Gastroparesis * Chronic/idiopathic acute pancreatitis * Hepatic disease or cirrhosis * Struggle with alcohol or other substance abuse (heavy drinking (≥4 drinks/day or ≥8 drinks/week for women; ≥5 drinks/day or ≥15 drinks/week for men), or who score ≥3 on the Drug Abuse Screening Test (DAST-10)) * Diabetes (Type 1 or 2) * Major risk factors for coronary heart disease such as uncontrolled high blood pressure (≥160 mm Hg systolic or ≥100 mm Hg diastolic) * Problems with your muscles or bones that limit your ability to exercise * Any other medica…