The goal of this clinical trial is to evaluate the impact of supervised training program on body composition, muscular strenght, insulino-resistance profile, heart rate variability and on heart structure and function between 3 to 6 months after mixed bariatric surgery or restrictive bariatric surgery. This study will be conducted in men and women with severe obesity. Respectively for each type of surgery (mixed vs. restrictive), participants will be randomized either to the exercise group or to the control group. For participant randomized in the exercise group, 3 months after the bariatric surgery, they will started a supervised exercise program for 3 months. In contrast, for participant randomized in the control group, they will have consultation with kinesiologist to receive general information about physical activity practice. Each participants will perform 4 evaluations; one before bariatric surgery and 3 after bariatric surgery (3 months, 6 months and 12 months). Thoses evaluations will be assessed at each visit : fasting blood draw, anthropometric measurements, cardiac echocardiography, heart rate variability measurement, mid-thigh and abdominal computed tomography scan, maximal exercise test, six-minute walk test, assessment of lower-limb endurance and strength, assessment of physical activity level and energy expenditure.
Age range
18 Years
Sex
ALL
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Change in abdominal adipose tissue (visceral) as measured by computed tomography (cm2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Change in abdominal adipose tissue (subcutaneous) as measured by computed tomography (cm2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Change in thigh muscle tissue (normal density) as measured by computed tomography (cm2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Change in thigh adipose tissue (subcutaneous) as measured by computed tomography (cm2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Change in thigh adipose tissue (deep) as measured by computed tomography (cm2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Muscular strength (upper-limb) assessed through handgrip via maximal voluntary contraction (kg)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Muscular relative strength (upper-limb) assessed through handgrip via maximal voluntary contraction (ratio)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Muscular strength (lower-limb) assessed through the femoral quadriceps via maximal voluntary contraction (Nm)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Muscular relative strength (lower-limb) assessed through the femoral quadriceps via maximal voluntary contraction (Nm/kg)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Change in insulin resistance (HOMA-IR)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Cardiac structure - Left ventricular mass (absolute) as assessed by transthoracic echocardiogram (g)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Cardiac structure - Left ventricular mass (relative) as assessed by transthoracic echocardiogram (g/m2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Cardiac function - Diastolic function as assessed by transthoracic echocardiogram (function/dysfunction, 1 to 3 dysfunction grade scale)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Time (SDNN) as assessed by a 24-hour Holter (ms)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Time (SDRR) as assessed by a 24-hour Holter (ms)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Time (SDANN) as assessed by a 24-hour Holter (ms)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Time (pNN50) as assessed by a 24-hour Holter (ms)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Time (RMSSD) as assessed by a 24-hour Holter (ms)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Frequency (VLF power) as assessed by a 24-hour Holter (ms2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Frequency (LF power) as assessed by a 24-hour Holter (ms2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Frequency (HF power) as assessed by a 24-hour Holter (ms2)
Timeframe: Before surgery and 3, 6 and 12 months post surgery
Heart rate Variability - Frequency (LF/HF) as assessed by a 24-hour Holter (ratio)
Timeframe: Before surgery and 3, 6 and 12 months post surgery