Left Atrial and Left Ventricular Structural and Functional Evaluation by CCTA for Predicting Post… (NCT07651046) | Clinical Trial Compass
WithdrawnNot Applicable
Left Atrial and Left Ventricular Structural and Functional Evaluation by CCTA for Predicting Post-Ablation Outcomes in Patients With Atrial Fibrillation
Stopped: Protocol details were entered incorrectly; study withdrawn before any enrollment.
China0Started 2024-08-15
Plain-language summary
This study aims to evaluate whether structural and functional parameters of the left atrium and left ventricle, measured by cardiac computed tomography angiography (CCTA), can predict clinical outcomes after radiofrequency ablation in patients with atrial fibrillation (AF). Atrial fibrillation is a common heart rhythm disorder, and while catheter ablation is an effective treatment, some patients experience recurrence. Current predictive tools have limitations. This prospective observational study will enroll patients with AF scheduled for first-time radiofrequency ablation. All participants will undergo CCTA before the ablation procedure to assess left atrial and left ventricular volumes, ejection fraction, and strain parameters. After ablation, patients will be followed for 12 months to monitor recurrence of atrial arrhythmias. The primary outcome is the recurrence of atrial fibrillation or atrial tachycardia lasting more than 30 seconds after a 3-month blanking period. The study will determine whether CCTA-derived parameters improve risk stratification for post-ablation recurrence. Findings may help identify patients who are more likely to benefit from ablation or who may need additional therapy.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Meet the indications for radiofrequency ablation recommended by relevant atrial fibrillation diagnosis and treatment guidelines
. Age ≥ 18 years
. First-time radiofrequency ablation
Exclusion criteria
. history of cardiac ablation
. structural heart diseases, such as cardiomyopathy, valvular disease, heart failure, and acute myocardial infarction
. severe renal failure (estimated glomerular filtration rate \<30 ml/m2)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses CCTA scans to look at the structure of my left atrium and left ventricle before ablation — can you explain what that imaging involves and whether it would add any risk or extra steps to my care?
2The study is tracking whether atrial arrhythmia comes back after ablation — does participating mean my follow-up monitoring would be more intensive than what I'd get with standard care, and how long would I be followed?
3Since this trial is observational and focused on predicting outcomes rather than testing a new treatment, would joining it change anything about how my actual ablation procedure is performed?
4Is catheter ablation already the right next step for me, or should I be considering other options like medication first before we talk about whether this study even makes sense for my situation?
5Given that this trial is looking at structural features of the heart to predict who does well after ablation, could the CCTA results actually give my care team useful information that might influence my own treatment plan?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Recurrence of atrial arrhythmia after ablation
Timeframe: 12 months after ablation (following the initial 3-month blanking period)
Trial details
NCT IDNCT07651046
SponsorNanjing First Hospital, Nanjing Medical University