Improve Muscle Weakness in Patient With COPD (NCT07649850) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Improve Muscle Weakness in Patient With COPD
60 participantsStarted 2026-06-10
Plain-language summary
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone. The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD. These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.
Who can participate
Age range
50 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
* Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
* Mild to moderate disease severity according to GOLD criteria.
* Ability to participate safely in aerobic exercise training.
* Medically stable and cleared by a physician for pulmonary rehabilitation.
* Ability to understand and follow study instructions.
Exclusion Criteria:
* Acute COPD exacerbation or respiratory infection during the study period.
* Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
* Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
* Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
* Cognitive impairment affecting cooperation or informed consent.
* Participation in another structured rehabilitation program during the study period.
* Severe hypoxemia requiring continuous oxygen therapy during exercise.
* History of deep vein thrombosis or clotting disorders.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is listed as 'not yet recruiting' — do you know when it's expected to open, and would it make sense to pursue other treatments in the meantime rather than waiting?
2Since this trial doesn't have a traditional phase listed, what does that tell us about how much is already known regarding the safety and effectiveness of whatever approach they're testing for muscle weakness in COPD?
3The trial is focused on measuring muscle strength as its main outcome — can you help me understand how significant muscle weakness is in my specific case, and whether improving it is a priority for managing my emphysema or COPD right now?
4Are there already established pulmonary rehabilitation programs or treatments for COPD-related muscle weakness that I could start now, and how would those compare to what this trial might offer?
5What would my participation in this trial actually look like day-to-day — and given that it hasn't started recruiting yet, is there a way to get on a waitlist or find out more details before committing to anything?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.