Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an… (NCT07649681) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Gustabor Phase 2 - Treating Taste Changes During Cancer Therapy: A Randomized Study Evaluating an AI- Based Nutrition Intervention
Germany198 participantsStarted 2026-07-01
Plain-language summary
The study investigates taste disorders that commonly occur during or after cancer treatment, often leading to issues such as malnutrition and treatment discontinuation. Although many non-pharmacological recommendations exist, it is unclear which methods are suitable for which individuals.
This randomized study aims to compare the effectiveness of individualized dietary recommendations (Gustabor group) with the current standard of care -general recommendations (Control group). Participants will undergo an objective assessment of taste disorders using taste strips and questionnaires. Based on the results, the Gustabor group will receive both general and specific dietary suggestions. These will be accomapnied by AI-generated recipe suggestions tailored to specific taste disorders (e.g., more cold foods in cases of metallic taste). The control group will receive the current standard: a flyer containing general dietary advice for oncology patients previously shown to be beneficial for managing taste alterations. The primary endpoint is the PG-SGA score within 12 weeks of inclusion.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18
* Suffering from one of the following tumor entities: Multiple myeloma, melanoma, urogenital cancer or malignant tumor of the gastrointestinal tract
* Mainly oral nutrition
* Subjectively perceived tumor therapy-related taste disorder
* At least two clinical presentations planned within 12 weeks with a minimum interval of three weeks
* Ability to participate in nutritional intervention, including use of the online portal and implementation of recipe suggestions (e.g. resources and access to a kitchen), either independently or with third-party support (e.g. by relatives, outpatient care services).
Exclusion Criteria:
* Pregnancy
* Taste disorder explained by other causes (e.g. existing before therapy or COVID disease)
* Placement in an inpatient care facility
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial focuses on an AI-based nutrition intervention for taste changes during cancer therapy — since I'm dealing with taste problems that affect my eating, is addressing that something my care team thinks could meaningfully help my overall treatment experience?
2The trial is listed as 'not yet recruiting,' so do you know when it's expected to open, and should I be making any treatment decisions now that might affect whether I'd still be eligible once it starts?
3The primary outcome being measured is something called the PG-SGA score, which I understand tracks nutritional status — can you explain what that means for my situation, and whether my current nutritional health is something we should be actively managing regardless of this trial?
4This study covers several different cancer types including multiple myeloma, GI cancers, melanoma, and urogenital cancers — given my specific diagnosis, do you think the nutrition and taste challenges being studied here actually apply to what I'm going through with my treatment?
5Since this is listed as Phase NA rather than a traditional Phase 1, 2, or 3 trial, what does that mean for how much is already known about this kind of AI nutrition support, and are there existing standard-of-care options for taste and nutritional changes we should be trying first?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Patient-generated Subjective Global Assessment (PG-SGA) Score