Furosemide vs Placebo in Severe Preeclampsia Postpartum (NCT07648251) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Furosemide vs Placebo in Severe Preeclampsia Postpartum
Honduras186 participantsStarted 2026-06-15
Plain-language summary
This randomized, double-blind, placebo-controlled trial evaluates whether oral furosemide 40 mg, initiated 12 hours postpartum, reduces hospital length of stay compared to placebo (folic acid 5 mg) in postpartum women with severe preeclampsia. Secondary outcomes include need for rescue antihypertensive medications, weight reduction, and metabolic safety (hypokalemia, renal function). A total of 186 participants (93 per arm) will be enrolled across two hospitals in Honduras.
Who can participate
Age range
14 Years – 49 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Signed informed consent (assent for minors 14-17 years with parental/guardian consent)
* Confirmed severe preeclampsia (BP ≥160/110 mmHg, or lower BP with thrombocytopenia, hepatic dysfunction, renal insufficiency, pulmonary edema, or cerebral/visual symptoms)
* Postpartum (12-24 hours after delivery, vaginal or cesarean)
* Hemodynamically stable (no vasopressors for ≥6 hours)
* Preserved diuresis (\>30 mL/hour for ≥6 hours)
* Serum creatinine \<0.8 mg/dL
Exclusion Criteria:
* Current or chronic diuretic use (before or during pregnancy)
* Known allergy to sulfonamides or furosemide
* Active febrile illness
* Known chronic kidney disease (eGFR \<60 mL/min/1.73m²)
* Participation in another interventional trial
* Pregnancy (current - not applicable postpartum, but excludes undiagnosed concurrent pregnancy)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Hospital Length of Stay (Hours)
Timeframe: From first study dose (12 hours postpartum) up to hospital discharge, approximately 3 to 14 days