Rhythm Psychophysics With Parkinson's Patients (NCT07647913) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Rhythm Psychophysics With Parkinson's Patients
Canada34 participantsStarted 2026-09-01
Plain-language summary
The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine. The main questions it aims to answer are:
* Does dopamine shelter the ability to generate and maintain a regular tapping rhythm in the presence of disrupting sensory information?
* Does dopamine allow the adaptation of tapping speed in the presence of changing sensory information?
* Is the engagement of the motor system useful to improve the detection of changes in the tempo of sensory information?
Participants will be asked to perform a battery of simple rhythmic tasks On and Off medication to evaluate the effect of dopamine on their rhythmic skills.
Who can participate
Age range
40 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Parkinson's Disease diagnostic
* Stage 1 or 2 Hoenh-Yahr scale
* Taking immediate-release Levodopa
* MoCA score of 26 or above
Exclusion Criteria:
* Dementia
* Other neurodegenerative disease
* History of substance abuse
* History of hearing disorders
* History of neuropsychiatric disease
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study involves temporarily withdrawing Levodopa to measure how it affects rhythm and tapping ability — given my current medication schedule, how risky would it be for me to pause Levodopa, even briefly, and what symptoms might I experience during that time?
2The trial is measuring very specific things like inter-tap intervals and synchronization timing — can you explain what these rhythm tests might reveal about how Parkinson's is affecting my motor control, and whether that information would actually be useful for my own care?
3Since this trial is listed as 'not yet recruiting,' do you know when it's expected to open, and would it make more sense for me to focus on other treatment options in the meantime?
4This study appears to be observational and focused on understanding rhythm and timing in Parkinson's rather than testing a new treatment — is there any direct benefit to me as a participant, or would I mainly be contributing to research?
5Given that this is a Phase NA study focused on psychophysics rather than a new drug or therapy, how does participating here compare to pursuing other clinical trials that might offer a potential treatment benefit for my stage of Parkinson's?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Changes in mean inter-tap intervals following Levodopa withdrawal during rhythmic tapping tasks.
Timeframe: Between experimental sessions one and two, which will take place approximately one week apart.
2
Changes in constant error following Levodopa withdrawal during rhythmic tapping tasks.
Timeframe: Between experimental sessions one and two, which will take place approximately one week apart.
3
Changes in asynchronies following Levodopa withdrawal during rhythmic tapping tasks.
Timeframe: Between experimental sessions one and two, which will take place approximately one week apart.