The Impacts of Ashwagandha Supplementation on Diurnal Cortisol and Stress Among Women (NCT07647081) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Impacts of Ashwagandha Supplementation on Diurnal Cortisol and Stress Among Women
30 participantsStarted 2026-06
Plain-language summary
The purpose of this project is to better understand the role of ashwagandha on the stress response and wellbeing among healthy, stressed women.
Who can participate
Age range
18 Years – 45 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Female, ages 18-45
. No hormonal birth control
. Identify as having a regular sleep schedule (eg. sleep by 1am and wake by 9am)
. Identify as having a regular menstrual period between 27-32 days apart on average
. PSS score of 14 (moderate stress) or greater
. No expected changes in stress levels over the next 3 months and agree to not initiate any new stress-reduction behaviors before study start or during the study
Exclusion criteria
. Diagnosed major depressive disorder or generalized anxiety disorder in the last 3 months, any liver, kidney, or thyroid disorder/dysfunction/injury, or diabetes
. Using any medication related to cortisol or HPA function such as corticosteroids, antidepressants, anti-psychotics, CNS-depressants (benzodiazepines, non-benzodiazepine sedatives, barbiturates, anti-convulsants, anesthetics), thyroid medications, diabetic medications, or immunosuppressants
. Taken any form of ashwagandha within the last 3 months
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Diurnal Salivary Cortisol Change from Baseline to ~4 weeks and ~8 weeks
Timeframe: Baseline, ~4 weeks,. ~8weeks
2
HRV Change from Baseline to ~4 weeks and ~8 weeks
Timeframe: Baseline, ~4 weeks,. ~8weeks
Trial details
NCT IDNCT07647081
SponsorOklahoma State University Center for Health Sciences