CompletedNot Applicable

Body Weight Reduction and Metabolic/Biochemical Parameters in Overweight or Obesity

Poland53 participantsStarted 2016-05-10

Plain-language summary

This was a single-center prospective observational cohort study conducted in Poland in the context of routine metabolic outpatient care. The study assessed selected metabolic, biochemical, oxidative-stress, inflammatory, and body-composition parameters in individuals with overweight or obesity undergoing standard lifestyle-based body weight reduction management. Participants with BMI \> 25 kg/m² were followed before and after body weight reduction, while individuals with normal body weight served as a comparison group. The weight reduction management included individualized dietary recommendations, physical-activity guidance, health education, regular follow-up visits, fasting blood sampling, and body-composition assessment. The aim of the study was to evaluate whether body weight reduction is associated with changes in metabolic and biochemical parameters, with particular attention to glucose and lipid metabolism, oxidative stress, inflammatory markers, adipokines, cytokines, and body-composition changes.

Who can participate

Age range

18 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18-85 years * BMI \> 25 kg/m² * Overweight or obesity diagnosed on the basis of medical examination and body-composition assessment * Participation in routine lifestyle-based body weight reduction management in a metabolic outpatient clinic * Written informed consent to participate in the study Exclusion Criteria: * Lack of informed consent * Severe hepatic insufficiency * Severe renal insufficiency * Severe respiratory insufficiency * Severe circulatory insufficiency * Disturbances of consciousness * Treatment-resistant depression * Chronic alcohol abuse * Pregnancy * History of serious nervous system injury * Implanted cardiac pacemaker * Pharmacological treatment affecting glucose and/or lipid metabolism * Incomplete follow-up or incomplete laboratory data

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial is already completed — is there published data from it that you've seen, and does anything in those results suggest a particular approach to weight loss that might make sense for my situation?
2The trial focused on people with overweight or obesity, including abdominal obesity and metabolic syndrome — given my own health profile, would I have fit the kind of participants they studied, and how closely do my numbers match that group?
3Since the primary outcome was change in body weight, do you know what methods or interventions were being tested, and are any of those approaches something we should consider as part of my treatment plan?
4This trial had no specific phase listed, which can mean it was more of an observational or behavioral study rather than a drug trial — does that change how you'd interpret any findings compared to a randomized medication study?
5Are there ongoing trials or evidence-based programs for overweight or metabolic syndrome that you'd recommend I look into now, given that this one has already wrapped up?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Body Weight

Timeframe: Baseline and after body weight reduction, up to approximately 6 months

Trial details

NCT IDNCT07645105

SponsorMedical University of Silesia

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-09-30

View on ClinicalTrials.gov More Overweight , Obesity trials