Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction (NCT07644806) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Olive Oil Supplementation for Heart Failure With Reduced Ejection Fraction
United States40 participantsStarted 2026-07-01
Plain-language summary
The OLEA-HF study aims to explore whether daily supplementation of extra-virgin olive oil (EVOO) for 12 weeks during participation in a cardiac rehabilitation program (standard of care) is feasible in patients with heart failure with reduced ejection fraction (HFrEF). The investigators will also determine the effects of EVOO on functional capacity and quality of life.
Who can participate
Age range
18 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosed with HFrEF with left ventricular ejection fraction ≤35 %.
* Referred to and enrolled in the standard cardiac rehabilitation program at Sentara Cardiac Rehabilitation Center, but has not yet initiated/started cardiac rehabilitation (i.e., has not attended the first cardiac rehab session).
* Able and willing to comply with study procedures and provide informed consent.
Exclusion Criteria:
* Co-morbidity expected to limit survival (e.g., terminal illness).
* End-stage renal disease.
* Unstable fluid overload.
* Current pregnancy (self-disclose).
* Habitual use of EVOO greater than 4 tablespoons per day.
* Known allergy or sensitivity to olive oil or its components.
* Unwillingness or inability to incorporate EVOO or dietary recommendations.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial isn't recruiting yet — do you know when it's expected to open, and would it make sense for me to stay on standard HFrEF treatment in the meantime?
2The main thing this study seems to be measuring is whether people actually eat more olive oil and whether that shows up in their blood — does that mean it's still in an early stage of figuring out if this approach even works, rather than testing whether it improves my heart function directly?
3Since this is listed as 'Phase NA,' what does that tell you about how much safety and benefit data already exists for olive oil supplementation specifically in people with reduced ejection fraction like me?
4How would adding daily olive oil supplementation fit alongside the medications I'm already taking for HFrEF, and is there anything about my current diet or health status that could affect my eligibility or the results?
5Would pursuing this trial delay or interfere with any standard-of-care treatments you'd otherwise recommend for my HFrEF right now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in 24-hour dietary recall monounsaturated fatty acids (MUFA)
Timeframe: At baseline, and 12-week
2
Change in dietary compliance (plasma monounsaturated fatty acids)