The Effects of Different Anesthetics on the Brain's Neural Networks (NCT07644663) | Clinical Trial Compass
Not Yet RecruitingPhase 4
The Effects of Different Anesthetics on the Brain's Neural Networks
China120 participantsStarted 2026-06-09
Plain-language summary
This study aims to analyze the electroencephalographic power spectrum and connectivity during unresponsive states induced by propofol, esketamine and dexmedetomidine, respectively. It intends to explore the macro neural mechanisms underlying anesthetic unresponsiveness, so as to further elucidate the mechanisms by which anesthetics induce loss and recovery of consciousness. In addition, this study will identify neural biomarkers under general anesthesia for monitoring patients' actual intraoperative consciousness status. The findings will facilitate the development of monitoring indicators and devices reflecting intraoperative consciousness during general anesthesia, enabling more accurate assessment of patients' intraoperative consciousness status.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients scheduled for elective non-cardiac surgery;
* American Society of Anesthesiologists (ASA) physical status classification I-II;
* Aged 18 to 65 years, regardless of gender;
* Body mass index (BMI) greater than 18 kg/m² and no more than 31 kg/m²;
* Written informed consent voluntarily signed by the patient or legal authorized representative for participation in this study.
Exclusion Criteria:
Subjects meeting any one of the following items will be excluded from this study:
* Presence of severe cardiovascular diseases or hepatic and renal insufficiency;
* Hearing impairment;
* History of psychiatric disorders or communication disorders;
* Anticipated difficult airway;
* Pregnant or lactating women;
* History of allergic reaction or contraindication to any of the three anesthetic drugs used in this trial;
* Participation in other clinical trials within the past 3 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Permutation cross mutual information (PCMI) and PCMI-based brain networks
Timeframe: From baseline (awake) through loss of responsiveness to recovery of responsiveness
2
EEG functional connectivity
Timeframe: From baseline (awake) through loss of responsiveness to recovery of responsiveness