CompletedNot Applicable

Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery

Bulgaria40 participantsStarted 2019-09-30

Plain-language summary

A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval. Serum kynurenic acid (KYNA) and serotonin were measured preoperatively and 24 hours after each procedure. The study examined longitudinal dynamics of kynurenine pathway biomarkers, their variation across Pederson surgical difficulty grades, and their relationship with postoperative pain and state anxiety.

Who can participate

Age range

18 Years – 38 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Bilateral impacted mandibular third molars requiring surgical extraction * Age 18-38 years * Written informed consent * Ability to comply with study procedures Exclusion Criteria: * Systemic inflammatory disease * Autoimmune disease * Neurological disease * Psychiatric disorders * Chronic pain conditions * Use of immunomodulatory medications * Use of psychotropic medications * Use of analgesic medications * Pregnancy * Drug hypersensitivity * Active pericoronitis at enrollment

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Serum kynurenic acid (KYNA) concentration

Timeframe: Preoperative baseline and 24 hours postoperative at each operation

Serum serotonin concentration

Timeframe: Preoperative baseline and 24 hours postoperative at each operation

Trial details

NCT IDNCT07644065

SponsorPlovdiv Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-05-17

View on ClinicalTrials.gov More Impacted Third Molar trials