Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting (NCT07643194) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Cohort Study of Postoperative Cognitive Dysfunction After Off-Pump Coronary Artery Bypass Grafting
China600 participantsStarted 2026-05-24
Plain-language summary
This prospective cohort study aims to investigate postoperative cognitive dysfunction in patients undergoing off-pump coronary artery bypass grafting. Eligible patients will be enrolled before surgery and followed after surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment before surgery and at predefined postoperative time points. Perioperative clinical information, including preoperative assessment data, intraoperative monitoring parameters, and postoperative clinical data, will be collected. The study will evaluate the occurrence of postoperative cognitive dysfunction and explore its association with perioperative factors.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* Scheduled to undergo elective off-pump coronary artery bypass grafting
* American Society of Anesthesiologists physical status classification I to IV
* Able to complete preoperative cognitive assessments, including the Mini-Mental State Examination and the Montreal Cognitive Assessment
* Written informed consent provided by the patient or family member
Exclusion Criteria:
* Emergency surgery
* Pre-existing diagnosed cognitive impairment or history of psychiatric disease
* Preoperative cognitive impairment
* Severe neurological disease, such as sequelae of stroke, that may interfere with cognitive assessment
* Severe visual or hearing impairment that prevents completion of cognitive assessment
* Inability to understand Chinese or presence of language communication barriers
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is specifically about cognitive problems after off-pump bypass surgery — does my situation make me a candidate for off-pump surgery, and how does that approach compare to traditional on-pump bypass in terms of cognitive risks for someone like me?
2Since this trial is a cohort study measuring how often cognitive dysfunction actually occurs after this type of surgery, what are my personal risk factors for developing memory or thinking problems after bypass surgery, and how would my doctor monitor me for those changes?
3The trial isn't recruiting yet — if I might be interested in participating once it opens, what would that actually involve for me in terms of follow-up visits, cognitive testing, or other commitments on top of my recovery?
4Given that this is an observational study rather than a treatment trial, my doctor wouldn't be testing a new therapy — so if I do develop postoperative cognitive dysfunction, what treatment or support options would actually be available to me?
5How does the risk of cognitive decline after off-pump bypass surgery weigh against other treatment options I might have for my heart condition, and is this surgery even the recommended path for my specific case?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of Postoperative Cognitive Dysfunction
Timeframe: Postoperative Day 7, or 1 Day Before Hospital Discharge if Discharged Before Postoperative Day 7