Individualized Neuro-Modulation Paired With Cerebellar Therapy
United States30 participantsStarted 2026-06-30
Plain-language summary
The purpose of this project is to evaluate feasibility and preliminary efficacy of pairing personalized transcranial direct current stimulation (tDCS) with individualized rehabilitation therapy in people with cerebellar damage.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18-75 years
* Males and Females
* Disorders that predominantly affect the cerebellum: damage from stroke, tumor or degeneration (genetic or non-genetic causes, congenital hypoplasia).
Exclusion Criteria:
* Diagnoses or impairments that interfere with task execution or data interpretation.
* Heart pacemaker or other MRI-incompatible implanted metal device
* Metallic foreign body in their eye or head
* Experience with severe claustrophobia
* Experience discomfort from the MRI scan, such as excessive heating of tattoos
* Seizures or history of seizure disorder
* Alcohol or substance use disorder (self-report)
* Diagnosed history of severe psychiatric disorder such as depression, schizophrenia (self-report)
* Metallic foreign body in their eye or head (except the mouth e.g. dental fillings)
* Specific medications: tricyclic anti-depressants or neuroleptic medication
* Any medical condition (including orthopedic, pain, cardiopulmonary or other) that limits safe participation in exercise training
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Scale for the Assessment and Rating of Ataxia (SARA)
Timeframe: Assessed at pre-treatment, post-treatment, and at 3- and 6-month follow-ups.
2
Patient-Reported Outcome Measure of Ataxia
Timeframe: Assessed at pre-treatment, post-treatment, and at 3- and 6-month follow-ups.
Trial details
NCT IDNCT07642856
SponsorHugo W. Moser Research Institute at Kennedy Krieger, Inc.