Effects of Different Secukinumab Maintenance Regimens on Long-Term Outcomes in Patients With Psor… (NCT07642544) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Different Secukinumab Maintenance Regimens on Long-Term Outcomes in Patients With Psoriasis
China120 participantsStarted 2026-06-01
Plain-language summary
To evaluate the long-term efficacy of two maintenance treatment patterns of secukinumab-the standard maintenance group and the non-standard maintenance group-by assessing the median time to onset and incidence of secondary failure, as well as the time to regain response after dose escalation of secukinumab (including re-initiation of intensive dosing or shortening of the injection interval) in patients who experienced secondary failure.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years, with a clinical diagnosis of moderate-to-severe plaque psoriasis.
* Initiated secukinumab treatment at our center between January 2020 and December 2025, and completed the standard 5-week induction period.
* Achieved PASI 75 response at the end of the induction period.
* Had a clearly defined maintenance treatment pattern (standard or non-standard), with complete treatment records and regular efficacy assessments.
* Complete electronic medical record data available for extraction.
Exclusion Criteria:
* Failure to complete the induction period, or failure to achieve PASI 75 response by the end of the induction period.
* Irregular maintenance treatment pattern, or substantial missing data.
* Use of other targeted biologic agents or small molecule drugs during the maintenance period.
* Permanent discontinuation of treatment for non-efficacy reasons, such as pregnancy, severe infection, or malignancy.
* Participation in other interventional clinical trials that may confound efficacy assessment.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time to onset of secondary failure
Timeframe: 36 months
Trial details
NCT IDNCT07642544
SponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School