RecruitingNot Applicable

Lung and Heart Function Across Decades of Life in Health

United States200 participantsStarted 2024-08-01

Plain-language summary

The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations. This study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a "normal" control comparator group for veterans evaluated by PDCEN.

Who can participate

Age range

24 Years – 68 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 24-68 * No respiratory complaints (defined as modified Medical Research Council score = 0) * No use of respiratory medications Exclusion Criteria: * Non-English speaking * Pregnancy * BMI\>35 Kg/m2 * Tobacco smoking within prior year * Lifetime tobacco smoking of \>5 pack-years * Current inhaled cannabis use (any modality) \>2x weekly * Prior inhaled cannabis uses exceeding 2x weekly within the prior year * Illicit drug use (other than cannabis) * No prior or current major organ disease, including but not limited to: * Neuromuscular weakness * History of malignancy (other than non-melanoma skin cancer)-- HIV/AIDS * Autoimmune disease * Solid-organ or hematopoietic stem cell transplant * Cardiovascular disease (other than mild HTN; \< 140/90; controlled on 2 or less medications) * Poorly-controlled HTN (SBP\>140 or DBP\>90 or use of more than 2 anti-hypertensive medications) * Any history of congestive heart failure (CHF, either HFpEF or HFrEF) * Any history of arrythmia (including atrial fibrillation)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

Timeframe: 2 years

Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

Timeframe: 2 years

Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

Timeframe: 2 years

Trial details

NCT IDNCT07641413

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2030-12-31

Contact for this trial

Mehrdad Arjomandi, MD

415-221-4810 mehrdad.arjomandi@ucsf.edu

View on ClinicalTrials.gov More Pollution Related Respiratory Disorder trials

Plain-language summary

Who can participate

Age range

24 Years – 68 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

Timeframe: 2 years

Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

Timeframe: 2 years

Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.

Timeframe: 2 years