Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy (NCT07641361) | Clinical Trial Compass
RecruitingNot Applicable
Hydration Intervention to Decrease Side Effects Associated With GLP - 1 RA Therapy
United States30 participantsStarted 2026-06-15
Plain-language summary
This is a 17 - week study consisting of a one - week run - in period and a 16 - week intervention. The 16 - week pilot interventions aims to increase hydration in those beginning GLP - 1 RA therapy. Investigators aim to increase hydration to potentially decrease side effect severity, amount of side effects, and drug discontinuation associated with GLP - 1 RA therapy. The investigators are piloting to assess feasibility and preliminary efficacy of the intervention through examining participant retention, participant feedback, researcher and participant adherence to protocols, impact on hydration biomarkers, and participant reported GLP - 1 RA side effects.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18-60
* Recently prescribed a GLP-1RA (within one week of prescription)
* Fluent in English
* Willing to complete the study protocol
Exclusion Criteria:
* Children and adults \> 60 years of age
* Those not taking a GLP-1RA
* Those who have been on a GLP-1RA longer than one week
* Not fluent in English
* Those who are pregnant or planning on becoming pregnant during the duration of the study
* Unwilling to comply with study protocol
* People with cardiac implants
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is looking at whether a hydration intervention can reduce side effects from GLP-1 medications like semaglutide or tirzepatide — do you think dehydration is a concern for me specifically given my current health status, and would something like this be worth exploring?
2Since this trial is listed as Phase NA and is primarily measuring whether the hydration approach is acceptable and feasible rather than proving it works, what does that mean for what I could realistically expect to learn or gain from participating?
3The trial is tracking both a physiological hydration score and how hydrated I feel personally — how are those two things measured, and would participating require any tests or check-ins that might be difficult to fit into my routine?
4Given that this study focuses on managing side effects rather than treating my obesity or diabetes directly, should I be thinking about this alongside standard treatment, or is there a reason to prioritize one path over the other right now?
5Are there any risks specific to a structured hydration protocol that I should be aware of, especially if I have any kidney issues or take medications that affect fluid balance?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Acceptability of hydration plus
Timeframe: At week 16, which is the end of the program.
2
Feasibility of Intervention
Timeframe: At week 16, which is the end of the program.
3
Change in physiological hydration score
Timeframe: Baseline (week 0) to week 16 (post - program)
4
Change in perceived hydration level
Timeframe: Week -1 (run - in week) to week 16 (end of program)