Using Breath Tests to Study Gut Sulfur Changes During Dietary Therapy (NCT07640659) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Using Breath Tests to Study Gut Sulfur Changes During Dietary Therapy
Canada45 participantsStarted 2026-06-01
Plain-language summary
This study aims to test whether a short liquid-based diet, followed by a low-sulfur eating plan, is safe, manageable, and helpful for people with mild to moderate ulcerative colitis. Investigators want to see if this approach can improve gut health, lower inflammation, and reduce symptoms. Investigators will also test breath samples as an easy, non-invasive way to track gut bacteria activity and disease changes. Investigators believe this diet plan can reduce harmful gut bacteria that produce irritating sulfur compounds, leading to better gut health and measurable improvements that can be detected through breath testing.
Who can participate
Age range
19 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 19-70 years.
=Diagnosis of mild-to-moderate ulcerative colitis, defined by a partial Mayo score (pMayo) of 2-7.
* Evidence of active inflammation at enrollment, defined as:
* C-reactive protein (CRP) \> 5 mg/L; or
* Fecal calprotectin (FCP) \> 200 µg/g.
* Receiving stable medical therapy for ulcerative colitis for at least 8 weeks prior to enrollment.
* No corticosteroid use at the time of recruitment.
* Under consideration by the treating physician for treatment escalation or biologic switch due to inadequate response to current therapy.
Exclusion Criteria:
* Partial Mayo score (pMayo) \> 7.
* Pregnant or breastfeeding.
* Body mass index (BMI) \< 18 kg/m².
* History of an eating disorder.
* Severe psychiatric disorder.
* Severe medical conditions, including:
* Active cancer;
* Significant cardiovascular disease;
* Diabetes mellitus; or
* Severe food allergies.
* Known allergy or intolerance to corn, dextrose, or maltodextrin.
* Antibiotic use within 3 months prior to enrollment.
* Probiotic use within 3 months prior to enrollment.
* Use of herbal anti-inflammatory supplements during the study period, including but not limited to:
* Serrapeptidase;
* Curcumin;
* Boswellia; or
* Bromelain.
* History of major gastrointestinal surgery, including:
* Ostomy;
* Total colectomy; or
* Short bowel syndrome.
* Inability or unwillingness to comply with study procedures, including anticipated travel or other commitments that may interfere with participatio…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.