A Phase II Clinical Study of SYH2068 Injection in Adults With Elevated Lipoprotein(a) (NCT07640217) | Clinical Trial Compass
Not Yet RecruitingPhase 2
A Phase II Clinical Study of SYH2068 Injection in Adults With Elevated Lipoprotein(a)
120 participantsStarted 2026-07-30
Plain-language summary
The purpose of this study is to evaluate the efficacy and safety of SYH2068 injection in patients with elevated lipoprotein(a).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Male or female participants ≥18 years of age;
. Elevated Lp(a);
. Participants who have used lipid-lowering drugs continue to use a stable dose, and those who have not used do not start new lipid-lowering drugs;
. Presence of ASCVD or ASCVD risk stratification assessed as moderate or high risk;
. Participants are able to understand and cooperate to complete this study, voluntarily participate in this study, and sign the ICF.
Exclusion criteria
. Diseases that significantly affect Lp(a) during screening period,
. Major or unstable cardiovascular events occurring from 3 months before signing the ICF to randomization;
. Undergoing or expected to undergo peripheral arterial, coronary, or cerebrovascular revascularization surgery or other major surgery within 3 months prior to signing the ICF until randomization or during the study period;
. NYHA class III-IV at the time of signing the ICF or LVEF \<40% during the screening period;
. Type 1 diabetes or hereditary hemorrhagic disorder at screening;
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Percentage change in Lp(a) from baseline to Day 60~180