GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA (NCT07639333) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
France100 participantsStarted 2026-07
Plain-language summary
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
Who can participate
Age range
18 Years – 43 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* A stopped pregnancy with an intrauterine pregnancy diagnosed by ultrasound (embryo larger than 7 mm corresponding to a gestational age of 6 weeks and 5 days. This is justified by the fact that fetal fragment (FF) detection is possible at 5 weeks of gestation, or 7 weeks and 5 days)
* Expulsion of a pregnancy within the last 2 hours
* Patient fluent in French
* Enrolled in a social security program
* Has received oral and written information about the protocol and has signed a consent form to participate in this research.
Exclusion Criteria:
* Diagnosis of an empty gestational sac, ectopic pregnancy, or unknown location
* Ultrasound findings consistent with a molar pregnancy
* Identified cause (preimplantation diagnosis, multiple uterine fibroids or a single fibroid \> 5 cm, uterine malformation affecting the uterine cavity, lupus, and antiphospholipid syndrome)
* Inability to obtain a blood sample
* Known current malignant tumor
* Blood transfusions within the last 3 months
* Cell therapy or immunotherapy within the last 3 months
* Previous organ transplant
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.