Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic… (NCT07639060) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
80 participantsStarted 2026-06
Plain-language summary
To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosis of chronic pain (generally pain duration of at least 3-6 months) localized to an anatomical region appropriate for cryoneurolysis as determined by the treating physician.
* Planned cryoneurolysis procedure as part of standard clinical care.
* Ability to provide written informed consent.
* Ability and willingness to complete baseline and follow-up questionnaires.
Exclusion Criteria:
* Cryoneurolysis performed as part of a separate investigational trial in which data sharing is not permitted.
* Active infection or other clinical contraindication to the procedure as determined by the treating clinician.
* Life expectancy of less than 12 months in the judgment of the treating clinician.
* Any condition that, in the investigator's opinion, would interfere with study participation or completion of follow-up, such as severe psychiatric instability or active substance use that precludes reliable follow-up
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is studying cryoneurolysis for a wide range of chronic pain conditions — from knee osteoarthritis to occipital neuralgia to spasticity — so could you help me understand whether my specific diagnosis is a good fit for what this trial is actually targeting?
2Since this is listed as Phase NA and hasn't started recruiting yet, what does that mean for the timeline of when I might actually be able to enroll, and should I be pursuing other treatments in the meantime rather than waiting?
3The trial is measuring whether participants see improvement in pain and changes in their Pain Disability Index score at 6 and 12 months — but as a case series rather than a randomized controlled trial, how confident can we be in what the results will tell us about whether cryoneurolysis is truly effective versus other factors?
4Cryoneurolysis involves freezing nerves to reduce pain signals — what are the known risks of that procedure for my specific condition, and are there standard treatments I haven't yet tried that my care team would recommend before considering something like this?
5If I were to eventually join this trial and the cryoneurolysis doesn't help or my pain gets worse over the 12-month follow-up period, what would my options be for switching to or adding other treatments during that time?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Percentage of participants with improvement in pain