AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years
* Histologically confirmed large B-cell lymphoma
* Presence of one or more high-risk features
* Eligible to receive CAR-T according to the FDA label
* Measurable disease by CT or PET
* Adequate organ function unless related to lymphoma involvement:
* Pulse oximetry ≥ 92% on room air
* Ejection Fraction ≥ 40%
* ALT/AST \< 5x ULN
* Bilirubin \< 3 x ULN
* Calculated or measured creatinine Clearance ≥ 30 mL/min
Exclusion Criteria:
* KPS \<60
* Second malignancy with a high metastatic potential within 3 years
* Active CNS involvement. Treated CNS disease is allowed
* Active HBV or HCV infection.
* Active uncontrolled infections
* Known HIV positive status
* Allogeneic transplant within 100 days of enrollment
* Active acute or chronic graft versus host disease
* History of acute or chronic pancreatitis
* History of myositis
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This is a Phase 1 trial that's still working out the safest dose of axatilimab — what does that mean for what's currently known about how safe and effective this combination with CAR-T therapy might be for my specific type of lymphoma?
2Since the trial isn't recruiting yet, how soon might it open, and would waiting to potentially join it affect my current treatment options or change how urgently I need to start something now?
3One of the main things this trial is measuring is 1-year progression-free survival — based on my individual situation, what would my doctor expect that number to look like compared to standard treatment paths available to me right now?
4Axatilimab targets a pathway involved in immune cell activity — can my doctor explain how adding it to CAR-T therapy might change the side effect profile compared to CAR-T alone, and are there any risks specific to my diagnosis I should be aware of?
5My condition falls under one of several lymphoma types this trial is enrolling — does my doctor think my specific diagnosis and treatment history would make this combination a reasonable thing to explore, or would a standard approach be a better first step?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Determine the recommended Phase 2 dose (RP2D) of axatilimab