Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabil… (NCT07638748) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment
United States10 participantsStarted 2026-06-12
Plain-language summary
The purpose of this study is to demonstrate feasibility, usability, and acceptability of VR-based cognitive and physical rehabilitation, evaluate adherence, tolerability, and fidelity to the VR intervention and explore preliminary effectiveness of VR-based rehabilitation on cognitive, physical, and functional outcomes
Who can participate
Age range
55 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Clinical diagnosis of MCI (MoCA 18-26) or self-reported subjective cognitive decline (SCD)
* Capacity to provide informed consent
* Able to provide own transportation to sessions
* Speaks and understands English
* Ambulatory
Exclusion Criteria:
* Uncontrolled seizures or epilepsy
* Severe psychiatric illness or active suicidality
* Inability to follow instructions or tolerate VR (severe motion sickness)
* Cognitive impairment as a result of a known cause (e.g., dementia, stroke, Traumatic Brain Injury (TBI), medications, etc.)
* Any condition that the research team determines would interfere with safe participation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is described as 'not yet recruiting' — do you know when it's expected to open, and would it make sense for me to wait for it or pursue other options in the meantime?
2Since this is a feasibility study rather than a treatment trial, it's mainly checking whether the VR program is practical and tolerable — not proving it improves cognition — so what realistic benefit, if any, might I personally get from taking part?
3The study tracks simulator sickness as a safety measure, so is there anything about my health history, like motion sensitivity or vision problems, that might make using VR headsets uncomfortable or risky for me?
4My condition is listed as mild cognitive impairment or subjective cognitive decline — given where I am in my diagnosis, do you think I'd be an appropriate candidate for this kind of study, and is there standard care I should be prioritizing first?
5The program involves repeated VR sessions requiring me to show up consistently and engage with the technology — given my day-to-day situation, do you think the time commitment and technology demands are realistic for me to manage?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Feasibility as assessed by the recruitment rate
Timeframe: from baseline to end of intervention (6 weeks)
2
Feasibility as assessed by the retention rate
Timeframe: from baseline to end of intervention (6 weeks)
3
Feasibility as assessed by the session completion rate
Timeframe: from baseline to end of intervention (6 weeks)
4
Usability as assessed by the System Usability Scale (SUS)
Timeframe: Post-intervention only (Final visit at 6 weeks)
5
Acceptability / Presence as assessed by the Presence Questionnaire (PQ)
Timeframe: Post-intervention only (Final visit at 6 weeks)
6
Tolerability / Side Effects as assessed by the Simulator Sickness Questionnaire (SSQ)
Timeframe: Before + immediately After each VR session
7
Adherence / Engagement as assessed by the session attendance as entered in VR system logs
Trial details
NCT IDNCT07638748
SponsorThe University of Texas Health Science Center, Houston