Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery (NCT07638306) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
Romania150 participantsStarted 2026-06-01
Plain-language summary
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are:
1. Can the internal jugular vein collapsibility index before anesthesia predict low blood pressure during induction?
2. Can the change in internal jugular vein collapsibility from before to just after anesthesia predict low blood pressure during surgery and acute kidney injury after surgery?
Participants will have routine ultrasound scans of the neck before anesthesia and again shortly after they fall asleep for surgery. Researchers will also record blood pressure during surgery and measure kidney function after surgery using routine blood tests. and again shortly after they fall asleep for surgery. Researchers will also record blood pressure during surgery and measure kidney function after surgery using routine blood tests.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Elective or Urgent (Non-emergent) major abdominal/ visceral surgery under general anesthesia
* General anesthesia with propofol induction (TCI/ manual)
* Expected surgical duration \> 60 minutes
* Continous BP monitoring (Invasive arterial line or non-invasive cuff at 2 minute recording intervals)
* Serum creatinine and eGFR (CKD-EPI) available within 30 days prior to surgery
* Written informed consent obtained before surgery
* Patient accessible by phone 30 days postoperatively
Exclusion Criteria:
* Emergency surgery (immediate life-saving, consent unobtainable)
* End-stage renal disease (eGFR \< 15 mL/min/1.73 m²) or dialysis-dependent
* Concomitant cardiac surgery or carotid endarterectomy
* Liver transplantation
* Known Internal Jugular Vein/ Inferior Vena Cava thrombosis or Superior Vena Cava syndrome
* Any anatomical neck abnormalities precluding Internal jugular vein ultrasound
* Induction with ketamine or etomidate as sole Induction agent
* Neuraxial anesthesia (spinal or epidural) before propofol induction
* Active decompensated heart failure (NYHA IV or acute pulmonary edema at time of Surgery)
* Same-admission reoperation within 30-day study window
* Withdrawal of consent at any point
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is focused on using ultrasound of the neck veins to predict low blood pressure during anesthesia induction — how would having this kind of monitoring before my abdominal surgery potentially change how my anesthesia team manages my care?
2The trial is measuring something called the Internal Jugular Vein Collapsibility Index as a way to predict blood pressure drops after propofol is given — can you explain what that means in plain terms and whether this type of monitoring is already used at our hospital?
3Since this trial isn't recruiting yet, is there a similar study or standard monitoring approach already available that could help reduce my risk of low blood pressure during surgery, which the trial seems to suggest is linked to kidney injury afterward?
4The study is focused on intraoperative hypotension and acute kidney injury after abdominal surgery — given my specific health history, how concerned should I be about those risks, and would participating in a study like this be relevant to my situation?
5Since this trial is in Phase NA and hasn't started recruiting yet, what does that mean for how much is currently known about the safety and usefulness of this ultrasound approach, and should I wait for results before my surgery or are there other ways to address these risks now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Post-induction hypotension
Timeframe: Periprocedural
2
Change in Internal Jugular Vein Collapsibility Index
Timeframe: From pre-induction to immediate post-induction
Trial details
NCT IDNCT07638306
SponsorTîrgu Mureș Emergency Clinical County Hospital, Romania