Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsi… (NCT07638176) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
48 participantsStarted 2026-06-01
Plain-language summary
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.
Who can participate
Age range
19 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* American Society of Anesthesiologists Physical Status I - III
* The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2
* Lung resection surgery requiring one-lung ventilation for over 60 minutes
* Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr)
* Patient who is diagnosed with intrinsic PEEP during one-lung ventilation
Exclusion Criteria:
* Large bullae
* Emergency surgery
* Mechanical ventilation before surgery
* Hemodynamic instability before surgery
* Surgery requiring cardiopulmonary bypass
* Pregnancy, breastfeeding patient
* Patient's refusal to participate
* No intrinsic PEEP during one-lung ventilation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Intrinsic positive end-expiratory airway pressure
Timeframe: During a 30-minute period from the start of one-lung ventilation to the completion of the intervention
2
Stroke volume
Timeframe: During a 30-minute period from the start of one-lung ventilation to the completion of the intervention