Impact of Targeted Therapy on Cancer-Related Cognitive Impairment

Inclusion Criteria: * TKI RECIPIENTS: Participants must have a diagnosis of CML or CLL * TKI RECIPIENTS: Participants must be scheduled to receive their first dose of TKI therapy for CML or CLL within 30 days or have received their first dose of TKI therapy for CML or CLL within the previous 30 days * TKI RECIPIENTS: Participants must be ≥ 18 years of age * TKI RECIPIENTS: Participants must be able to speak and read English * TKI RECIPIENTS: Participants must be able to understand and willing to sign an informed consent document * CANCER-FREE INDIVIDUALS SERVING AS CONTROLS: Participants must be ≥ 18 years of age * CANCER-FREE INDIVIDUALS SERVING AS CONTROLS: Participants must be able to speak and read English * CANCER-FREE INDIVIDUALS SERVING AS CONTROLS: Participants must be able to understand and willing to sign an informed consent document * CANCER-FREE INDIVIDUALS SERVING AS CONTROLS: Each participant must be matched to a TKI recipient participant based on sex and age ±5 years (i.e., must be no more than 5 years older or younger than the TKI recipient participant) Exclusion Criteria: * Participants must have no history of metastatic cancer, primary brain tumor, or brain irradiation * Participants must have no history of TKI therapy * Participants must have no history of cytotoxic chemotherapy, immune checkpoint inhibitor therapy, hormonal therapy, biologic therapy, radiotherapy within the past 5 years. However, permitted treatments include prior use of hydroxyurea for…