The goal of this clinical trial is to determine whether tocotrienol works as a senolytic agent to delay age-related biological changes in middle-aged adults. The study will also evaluate the safety of tocotrienol supplementation. The main questions it aims to answer are: Does tocotrienol reduce markers of cellular senescence, inflammation, oxidative stress, and mitochondrial dysfunction? What health changes or medical issues occur in participants taking tocotrienol? Researchers will compare tocotrienol-rich fraction to a placebo (a look-alike capsule with no active ingredient) to determine whether tocotrienol is effective in modulating aging-related pathways. Participants will: Take tocotrienol (200 mg/day) or a placebo daily for 6 months Attend study visits at baseline, 3 months, and 6 months for clinical assessments and laboratory tests Undergo blood sampling and health evaluations, including measures of senescence-associated secretory phenotype (SASP), inflammation, oxidative stress, mitochondrial function, vascular health, skin status, cognitive function, body composition, and bone mineral density. Complete questionnaires related to diet throughout the study period This study aims to provide clinical evidence on the potential of tocotrienol as a senolytic intervention for promoting healthy aging and reducing the risk of age-related diseases.
Age range
35 Years – 50 Years
Sex
ALL
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Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Blood pressure
Timeframe: Baseline, Month 3 and Month 6
Changes in Advanced Glycation End Products (AGEs)
Timeframe: Baseline, Month 3, and Month 6
Changes in Protein Carbonyl
Timeframe: Baseline, Month 3, and Month 6
Change in Malondialdehyde (MDA)
Timeframe: Baseline, Month 3, and Month 6
Change in DNA Damage
Timeframe: Baseline, Month 3, and Month 6
Body Composition assessment
Timeframe: Baseline, Month 3, and Month 6
Food intake questionnaire
Timeframe: Baseline, Month 3, and Month 6
Changes in SASP Gene expression
Timeframe: Baseline, Month 3, and Month 6
Change in SASP Protein expression
Timeframe: Baseline, Month 3, and Month 6
Change in Tumor Necrosis Factor-Alpha (TNF-α)
Timeframe: Baseline, Month 3, and Month 6
Change in Inteleukin-6 (IL-6)
Timeframe: Baseline, Month 3, and Month 6
Change in ATP production
Timeframe: Baseline, Month 3, and Month 6
Change in Mitochondrial Complex V Enzyme Activity
Timeframe: Baseline, Month 3, and Month 6
Change in Mitochondrial Membrane Potential
Timeframe: Baseline, Month 3, and Month 6
Change in Plasma Alpha-Tocotrienol Concentration
Timeframe: Baseline, Month 3, and Month 6
Change in Plasma Gamma- Tocotrienol Concentration
Timeframe: Baseline, Month 3, and Month 6
Change in Total Plasma Tocotrienol Concentration
Timeframe: Baseline, Month 3, and Month 6