Dry Weight Reduction Intervention Via Extra Ultrafiltration (NCT07637110) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Dry Weight Reduction Intervention Via Extra Ultrafiltration
United States120 participantsStarted 2026-06
Plain-language summary
Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease. This extra fluid is the main cause of high blood pressure in dialysis and leads to stress on the heart and lungs.that causes debilitating symptoms and frequent hospitalizations.
This trial will test whether a focused program of 4 or 8 weeks of extra ultrafiltration treatments can remove most of this extra fluid. We believe that getting rid of large amounts of extra fluid will result in sustained improvements in blood pressure and symptoms. Ultrafiltration is a gentler type of dialysis that removes fluid but does not clean the blood.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Persistent hypertension defined by three consecutive pre-dialysis systolic blood pressures ≥140 mmHg or three consecutive pre-dialysis systolic blood pressures 130-140 mmHg plus use of at least two anti-hypertensive medications that can be tapered.
. Symptoms of congestion defined by a 12-item Kidney Modified Kansas City Cardiomyopathy Questionnaire (KM-KCCQ) score \<75.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial focuses on reducing dry weight through extra ultrafiltration during dialysis to manage blood pressure and fluid buildup — how would my current fluid status and blood pressure control affect whether this approach might be worth trying for me?
2Since this trial isn't recruiting yet, how far off do you think it might be before it opens, and should I be considering other options in the meantime rather than waiting?
3The trial is measuring 24-hour ambulatory blood pressure monitoring — is that something I'd need to wear continuously, and how realistic is that kind of commitment given my current dialysis schedule and daily life?
4Extra ultrafiltration means removing more fluid during dialysis sessions, which can sometimes cause cramping or low blood pressure — how would you weigh those risks against the potential benefit of better long-term blood pressure control for someone in my situation?
5Since this study is listed as 'Phase NA,' meaning it may be more of an interventional procedure study than a traditional drug trial, what do we actually know so far about the safety and effectiveness of adjusting dry weight this way in people with end-stage renal disease?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
24-hour continuous ambulatory blood pressure
Timeframe: Measurement performed at baseline compared to measurement performed at 24 weeks.
2
Symptoms of congestion.
Timeframe: Questionnaire taken at Baseline compared the the questionnaire taken at 24 weeks.