BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence (NCT07636213) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence
United States270 participantsStarted 2026-07-01
Plain-language summary
The purpose of this research study is to prospectively collect biospecimens, imaging, and clinical data from patients with penetrating brain injuries across high-volume PBI sites in the US (including UChicago). Biospecimens will undergo biomarker analysis - biomarker data specific to PBI is extremely limited, and could provide critical insight to outcome identification and clinical decision making.
This data will be used to build the first comprehensive PBI Data Commons, biorepository, and imaging repository which will create the infrastructure necessary to close critical knowledge gaps, advance biomarker discovery specific to PBI, and provide the foundation for future research aimed at improving prognostication and treatment for patients with this devastating injury.
Who can participate
Age range
16 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Age: Subjects aged 16 years and older
. Injury Type/Evidence: Patients with a confirmed PBI as demonstrated by head imaging or physical exam (evidence of dural penetration by a projectile)
. Timeframe: Patients must be enrolled within 8 hours of injury
Exclusion criteria
. Dead on Arrival (DOA): Patients who receive CPR with no return of pulse
. Non-penetrating injury: Patients with head injuries that do not include dural penetration
. Polytrauma: Patients with penetrating or blunt injuries to other parts of the body
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial seems focused on building a data and tissue repository rather than testing a treatment — does that mean there's no direct therapeutic benefit for me or my family member, and if so, how does that change whether it's worth participating?
2Since the trial isn't recruiting yet, how long might it realistically be before it opens, and in the meantime, what treatment or care options should we be pursuing for this penetrating brain injury?
3What exactly would participation involve — would my family member need to provide tissue samples, imaging scans, or ongoing data, and how demanding would that be given everything else we're managing right now?
4Because this is listed as Phase NA, which typically means it's an observational or infrastructure study rather than a treatment trial, can you help me understand what other clinical trials or standard-of-care options might actually target the acute traumatic brain injury itself?
5Who controls access to the data and biosamples collected in this repository, and what privacy protections would be in place if my family member's brain imaging or biological material is stored and shared with researchers?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Building the first PBI Data Commons, Biorepository, and Imaging Repository