RecruitingNot Applicable

Comparison of Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer

China52 participantsStarted 2026-05-01

Plain-language summary

This study includes patients diagnosed with proximal gastric cancer (Siewert type II/III, cT1-3N0-1M0) across six tertiary hospitals, who underwent either double-tract reconstruction (DTR) or tubular gastric anastomosis (TGA). Participants were divided into two groups based on the surgical procedure. We conducted a comparative analysis of postoperative outcomes by evaluating electronic medical records, postoperative gastroscopy, 24-hour esophageal pH monitoring, and relevant rating scales.

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pathologically confirmed gastric adenocarcinoma by biopsy * Carcinoma of the upper gastric body or Siewert type II/III adenocarcinoma of the esophagogastric junction (AEG), with a clinical stage of cT1-3N0-1M0 * Age 18-75 years, with a performance status (PS) score of 0-2 * Candidates for planned surgical resection, eligible for either double-tract reconstruction or tubular gastric anastomosis based on preoperative assessment * No severe dysfunction of vital organs (liver, kidney, heart, lung, or brain), and no severe infection or uncontrolled chronic diseases Exclusion Criteria: * Presence of other malignant tumors or severe chronic diseases (e.g., severe diabetes mellitus, chronic kidney disease, decompensated cirrhosis, etc.) * Preoperative endoscopic diagnosis of Barrett's esophagus * Severe preoperative malnutrition (albumin \<30 g/L, prealbumin \<150 mg/L) * History of prior upper abdominal surgery, gastrointestinal malformation, or psychiatric disorders * Preoperative diagnosis of obstructive motor disorders of the cardia (including achalasia spectrum disorders) * Inability to cooperate with or complete the required postoperative examinations

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial is comparing two types of reconstruction after surgery for proximal stomach cancer — a double-tract method versus a tubular gastric approach — and it's specifically measuring reflux esophagitis after surgery, so could you explain what reflux esophagitis is and why the choice of reconstruction technique might affect how likely I am to develop it?
2Since this trial is listed as Phase NA, which often means it's a surgical procedure comparison rather than a drug trial, what does that mean for how much is already known about the safety and outcomes of each of these two surgical techniques?
3The trial is actively recruiting right now, so if I were to discuss participation with you, would joining this study change which surgical reconstruction I'd receive, or would that decision be made randomly as part of the study design?
4Beyond reflux esophagitis, are there other meaningful differences between the double-tract and tubular gastric reconstruction approaches — such as effects on digestion, nutrition, or quality of life — that I should weigh when thinking about whether this trial is worth discussing further?
5If I'm not a good candidate for this trial, or if I decide not to participate, which of these two reconstruction techniques would you recommend for my specific situation and why?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Incidence of postoperative reflux esophagitis

Timeframe: 6 month after surgery

Severity of reflux esophagitis

Timeframe: 6 month after surgery

Trial details

NCT IDNCT07635836

SponsorQilu Hospital of Shandong University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-05-01

Contact for this trial

Hui Qu, Doctor of Medicine

+8618560085120 doctorquhui@email.sdu.edu.cn

View on ClinicalTrials.gov More Gastric Cancer (GC) trials