Validation of the Association Between the Abundance of Three Bacterial Genera in Stool Samples an… (NCT07635745) | Clinical Trial Compass
CompletedNot Applicable
Validation of the Association Between the Abundance of Three Bacterial Genera in Stool Samples and the Risk of Gallbladder Cancer in South American Patients With Gallstones
In our previous work, we found three types of bacteria in stool samples from South American patients with gallstones linked to a higher risk of gallbladder cancer. The aim of the present study is to confirm these associations using a separate set of South American stool samples.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with gallstones and cancer-free OR - Patients with gallbladder cancer
Exclusion Criteria:
* Antibiotics use
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study looked at specific bacteria in stool samples to predict gallbladder cancer risk in people with gallstones — given that I have gallstones, is this kind of microbiome-based risk assessment something that could or should be part of my care?
2The trial used shotgun metagenomic sequencing to measure three specific bacterial genera in stool — can you explain what those bacteria are and what it would mean if someone's levels were considered high or low risk for gallbladder cancer?
3Since this trial is now completed, has the research been published yet, and does the evidence look strong enough that it might change how you monitor or counsel patients like me who have gallstones?
4This study focused specifically on South American patients — do you think those findings would apply to my situation given my own background and where I live, or are there limits to how far these results can be generalized?
5Rather than waiting for microbiome testing to become routine, what signs or symptoms should I already be watching for that might suggest my gallstones are putting me at higher risk for gallbladder cancer?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Validation of the Association Between Gallbladder Cancer Risk in South American Patients With Gallstones and the Centered Log-Ratio-Transformed Abundance of Three Stool Bacterial Genera Determined by Shotgun Metagenomic Sequencing