Early Time-Restricted Eating for Cardiovascular Health (NCT07634926) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Early Time-Restricted Eating for Cardiovascular Health
United States36 participantsStarted 2026-08-01
Plain-language summary
This study will examine whether eating earlier in the day within a consistent 8-hour eating window can improve heart and blood vessel health in older adults with high blood pressure who often skip breakfast. Participants will be randomly assigned to either follow an early time-restricted eating schedule or continue their usual eating habits for 12 weeks. Researchers will measure blood pressure, blood vessel function, and biological markers related to the body's internal clock and oxidative stress to better understand how meal timing affects cardiovascular health.
Who can participate
Age range
60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men and women ≥ 60 years old
* Average office systolic BP ≥130 mmHg5
* Self-reported skipping breakfast for at least 3 days in the past 7 days
* Identified as having a morning or evening chronotype according to the Morningness-Eveningness Questionnaire68
* Stable health history over the past 2 months
* Stable medication history over the past 2 months, as recommended by the primary provider
* Willing and able to provide informed consent.
Exclusion Criteria:
* Fasting \>13 hours per day
* Actively trying to lose weight by participating in formal weight loss program or significantly restricting calorie intake
* Resting heart rate of \>120 beats/minute, systolic BP \>180 and/or diastolic BP \>100 mmHg
* Have lost ≥ 10 pounds in last 3 months
* Self-reported exercise over 90 min/week
* Unable to wake up at a regular time between 6-9 am
* Perform overnight shift work more than 1day/week on average
* Have been diagnosed with diabetes
* On insulin or diabetes medication
* Unstable angina, heart attack or stroke in the past 3 months
* Continuous use of supplemental oxygen to manage a chronic pulmonary condition or heart failure
* Pregnant or breastfeeding
* Rheumatoid arthritis, Parkinson's disease or currently on dialysis
* Current diagnosis of a major psychiatric condition that would impair study participation
* Severe gastrointestinal disease, major gastrointestinal surgery, or active gallstone disease
* Active treatment for cancer in the past year
* Taking…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
24-Hour Systolic Blood Pressure
Timeframe: Baseline (Week 0), Week 6, and Week 12 of the intervention