Effects of Resveratrol Supplementation Combined With a Low-Calorie Diet in Postmenopausal Women W… (NCT07634302) | Clinical Trial Compass
CompletedNot Applicable
Effects of Resveratrol Supplementation Combined With a Low-Calorie Diet in Postmenopausal Women With Obesity and Knee Osteoarthritis
Russia97 participantsStarted 2017-03-20
Plain-language summary
Obesity is a major modifiable risk factor for knee osteoarthritis and is associated with chronic low-grade inflammation, pain, functional impairment, and cartilage degradation. Weight reduction is recommended as a core component of osteoarthritis management, while resveratrol has demonstrated anti-inflammatory and chondroprotective properties in experimental and clinical studies. However, the potential additional benefit of resveratrol supplementation when combined with dietary intervention remains uncertain.
This randomized controlled trial evaluated the effects of 150 mg/day trans-resveratrol supplementation as an adjunct to a low-calorie diet in postmenopausal women with obesity and knee osteoarthritis. Ninety-seven participants were randomized to receive either a low-calorie diet alone or the same diet combined with resveratrol for 10 days. Outcomes included pain intensity, functional status, urinary C-terminal telopeptide of type II collagen (CTX-II), anthropometric parameters, body composition, metabolic markers, lipid profile, and inflammatory biomarkers.
Who can participate
Age range
45 Years – 75 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Postmenopausal women aged 45-75 years.
* Diagnosed knee osteoarthritis.
* Obesity, defined as BMI ≥30 kg/m².
* Ability to comply with the study protocol and dietary recommendations.
* Written informed consent to participate in the study.
Exclusion Criteria:
* Allergy or intolerance to grapes, wine, peanuts, resveratrol, or supplement components.
* Acute infectious or inflammatory disease at screening.
* Unstable or exacerbated chronic disease requiring treatment changes or hospitalization.
* Malignancy within the past 5 years.
* Chronic liver disease, including hepatitis or cirrhosis.
* Major cardiovascular event within the past 6 months.
* Alcohol abuse or dependence.
* Severe psychiatric disorder or cognitive impairment limiting protocol adherence.
* Use of resveratrol-containing supplements or investigational products within the past 6 months.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial combined resveratrol supplements with a low-calorie diet specifically in postmenopausal women with both obesity and knee osteoarthritis — do I fit that profile closely enough for the results to be relevant to my situation?
2The trial measured something called urinary CTX-II, which tracks cartilage breakdown, alongside pain scores and an inflammation marker called hsCRP — based on those outcomes, did the combination of resveratrol and calorie restriction actually show meaningful changes in my knee's cartilage health or just in pain relief?
3Since this trial is already completed, is the full results data available yet, and would you be able to walk me through whether the findings were strong enough to consider trying resveratrol supplementation as part of my treatment plan?
4A low-calorie diet was a key part of this intervention, not just the supplement — do you think the diet change alone could account for any improvements seen, and is that something worth trying on its own before adding resveratrol?
5Are there any safety concerns about taking resveratrol supplements at the doses used in this trial, especially given that it was listed as 'Phase NA,' meaning it may not have gone through the same safety vetting as a standard drug trial?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Urinary CTX-II
Timeframe: Baseline and Day 10
2
WOMAC Score
Timeframe: Baseline and Day 10
3
Pain Intensity (VAS)
Timeframe: Baseline and Day 10
4
hsCRP
Timeframe: Baseline and Day 10
Trial details
NCT IDNCT07634302
SponsorFederal State Budgetary Scientific Institution