Additive vs Subtractive Manufacturing for Endocrown Fabrication: A 24-Month RCT (NCT07633574) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Additive vs Subtractive Manufacturing for Endocrown Fabrication: A 24-Month RCT
60 participantsStarted 2026-06
Plain-language summary
This randomized controlled trial (RCT) compares the 24-month clinical performance of endocrown restorations fabricated by two digital manufacturing pathways: additive manufacturing using 3D-printed ceramic-filled photopolymer resin (VarseoSmile TriniQ, BEGO) versus subtractive computer-aided design/computer-aided manufacturing (CAD/CAM) milling from hybrid nano-ceramic blocks (HC Hard Block, Shofu). Sixty endocrowns will be placed in endodontically treated posterior molars and evaluated using modified United States Public Health Service (USPHS) criteria at 6, 12, and 24 months. The trial is conducted at the Conservative Dentistry Department, Faculty of Dentistry, Cairo University.
Who can participate
Age range
25 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 25-45 years, male or female
* Endodontically treated molar tooth with radiographically confirmed treatment success and no clinical signs of failure
* Sufficient remaining coronal structure for endocrown preparation: minimum three walls, wall thickness 1.5 mm or greater, pulp chamber depth 3 mm or greater, supragingival preparation margins
* Completely erupted tooth with intact periodontal support
* Minimum of 20 occluding teeth
* Satisfactory oral hygiene status
* Capable of providing written informed consent and committed to scheduled follow-up visits
Exclusion Criteria:
* Diagnosed parafunctional habit or nocturnal bruxism
* Uncontrolled systemic illness or physical disability precluding safe participation
* Heavy tobacco use
* Current or suspected pregnancy
* Periapical disease or radiographic signs of endodontic failure
* Evidence of pathological tooth wear or occlusal erosion
* Moderate-to-severe periodontitis or tooth with hopeless prognosis
* Radiographic or clinical evidence of vertical root fracture
* Impaired decision-making capacity or anticipated non-compliance
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.