Lifestyle Intervention In CKD (NCT07633145) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Lifestyle Intervention In CKD
152 participantsStarted 2026-07-14
Plain-language summary
This research study will test whether a 12-week healthy lifestyle program offered through a cardiac rehabilitation center can help lower blood pressure and improve kidney health in adults with advanced chronic kidney disease. Participants will be randomly assigned to either routine kidney health education or take part in a program that includes healthy eating guidance, supervised exercise sessions, and wellness coaching. The goal of the study is to determine whether this program can improve blood pressure and other factors linked to worsening kidney disease.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Black race; ≥18 years old
* history of hypertension
* SBP ≥120 or DBP ≥80 mm Hg average of three measurements at screening visit (per KDIGO recommended SBP target of \<120 mm Hg)48
* Stable anti-hypertensive medication regimen (i.e., no medication changes 4 weeks prior to enrollment);
* eGFR of 15-44 ml/min/1.73m2 at screening visit
* agreeable to randomization to either of the 2 study arms
Exclusion Criteria:
* currently receiving or needing dialysis; having received or needing a kidney transplant
* acute kidney injury at time of screening
* average SBP ≥ 180 mm Hg or DBP ≥ 110 mm Hg at screening
* Exaggerated systolic response during ETT (e.g., SBP \>210 mmHg in men or \>190 mmHg in women)
* underweight (BMI \<18.5 kg/m2)
* planned weight loss surgery in 1 year
* a score of 27 or higher on the BP medication adherence scale
* cardiac condition that would preclude participation in aerobic exercise training, including severe ischemic heart disease (CCS Class 3 or 4 angina or evidence of ischemia at \<85% heart rate reserve on screening treadmill testing), severe heart failure (NYHA Class 3 or 4), high grade arrhythmias, severe valvular heart disease
* severe asthma or chronic obstructive lung disease
* musculoskeletal or neurologic conditions that would preclude participation in aerobic exercise training
* a major psychiatric disorder
* illicit drug abuse
* current alcohol consumption \>14 drinks/week for men and \>7 drinks/week for women
* pregnant or…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.