This multicenter, retrospective study develops and validates artificial intelligence (AI)-based semantic segmentation algorithms for intraprocedural transesophageal echocardiography (TEE) during Transcatheter Mitral Edge-to-Edge Repair (TEER). Using pooled imaging data from multiple high-volume structural heart centers, the study aims to automate recognition of mitral leaflets and MitraClip components, measure leaflet insertion length in real time, and display clip position and orientation. Algorithm performance will be benchmarked against expert manual annotations.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients (≥18 years of age) at the time of the index procedure
* Confirmed diagnosis of degenerative or functional mitral regurgitation
* Underwent Transcatheter Mitral Edge-to-Edge Repair (TEER) with the MitraClip device at one of the participating centers
* Intraprocedural transesophageal echocardiographic (TEE) imaging available, complete, and of sufficient quality to support semantic segmentation and real-time measurement analyses
* Appropriate consent for research use of clinical and imaging data, as per the policy of each participating center
Exclusion Criteria:
* Incomplete or poor-quality intraprocedural TEE imaging unsuitable for accurate segmentation and measurement
* Ambiguous or unconfirmed diagnosis of mitral regurgitation
* Documented refusal to allow use of clinical or imaging data for research purposes
* Missing essential clinical documentation required to confirm eligibility
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Accuracy of AI-based semantic segmentation of mitral valve leaflets and MitraClip device components
Timeframe: Intraprocedural (TEE images acquired during the TEER procedure)
2
Accuracy of automated real-time recognition of mitral leaflet insertion length
Timeframe: Intraprocedural (TEE images acquired during the TEER procedure)